Agnes Bloch-Zupan

Pamela Den Besten

Stefan Habelitz

Catherine Chaussain

Michael Lansdell Paine

Elia Beniash

Rodrigo S. Lacruz

Wendy J. Shaw

Henry Margolis

Meerim K. Nurbaeva

The Research Topic will host an overview of the most recent knowledge on enamel issued from a group of international experts who gathered at the 10th International Symposium on Dental Enamel (Enamel X). The Topic will include manuscripts describing original data, short communication, and reviews. In addition, the Topic will host abstracts and panel discussions presented at the Enamel X meeting, to highlight changing paradigms, unsolved and challenging questions, as well as translational challenges. Bringing together physics, chemistry, biochemistry and development and differentiation, contributions to this Topic will focus on the unique architecture of enamel, from nano- to macro- scale, and the dynamic molecular interactions with lead to extracellular self-assembly and mineralization. This knowledge will open a window into innovative bioinspired treatment and materials for tissue repair and regeneration. Tissue-specific networks and pathways shared with a number of biological systems (clock genes, epithelial polarization/ion handling, cell niche dynamics, and cell signaling) will also be explored. This will give an overall picture of the multiple acellular, cellular and organismal (essentially transgenic mice) processes actively investigated in the enamel field. Similarly, lessons from isolated or syndromic, inherited and acquired enamel defects obtained using cutting edge cell and matrix-omics will establish the emerging genomic framework determining enamel quality. Tooth enamel defects reflect historical and present gene-environment interactions in the animal and human condition such as climate, nutrition, pollutants or fluoride exposures. This last fact is highly relevant in medicine and public health since poor tooth quality and mineral defects are one of the first human worldwide pathologies.

Tooth Enamel Research: Enamel 10 and beyond

Crispian Scully

Heddie O. Sedano

Dental defects may be the physical expression of genetic defects, and so they can often be seen in a variety of syndromes associated with malformations of organs. However, dental defects are often not recognized, identified, nor characterised despite representing a possible diagnostic sign for an undiagnosed condition. This book addresses this gap by providing an understanding of dental genetics and its developmental biology counterpart. With approximately seventy well-illustrated examples, the authors present the clinical oro-facial manifestations accompanying various syndromes, providing the necessary knowledge for diagnostic purposes, as well as giving insight into recent development for each specific condition. The clarity and format of this book make it an ideal support guide both in the clinic and while conducting research. Comprehensive examination of dento/oro/craniofacial anomalies Well-illustrated examples Presented in a compact, easy to use format

Dento/Oro/Craniofacial Anomalies and Genetics

Agnes Bloch-Zupan

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