William E. Paul

Anthony Fauci

Sudhir Gupta

During the past 5 years rapid progress has been made in the understanding of biochemical pathways for signal transduction in lymphocyte activation. Gene cloning technology has been instrumental in defining and making available in pure form of a number of growth and differentiation factors, in the characterization of their receptors, and in the delineation of genes for the T cell receptor. This book is divided into 6 sections. Section 1 deals with the molecular structure of the T cell receptor. Section 2 discusses the role of the T cell receptor, membrane ion channels and biochemical pathways of signal transduction in T cell activation. The molecular structures and biological and immunological effects of interleukin 1, interleukin 2 and interleukin 3 are presented in Section 3. This section also details the structure of interleukin 2 receptor and its use as a target for therapy for certain leukemias. Section 4 includes the biochemical events which occur following the delivery of the signal for B cell activation, proliferation, and differentiation by antigen, growth/differentiation factors. The molecular structure of B cell stimulating factors is also discussed. The role of oncogene expression in cellular activation and differentiation is included in Section 5. The cellular and molecular basis of natural killing and the molecular basis of cyc1osporin A-mediated immunosuppression are discussed in detail in Section 6. We hope this book will serve as a reference work on basic mechanisms of lymphocyte activation, proliferation, and differentiation for immunologists and molecular biologists.

Mechanisms of Lymphocyte Activation and Immune Regulation

Dennis Kasper

Infectious Diseases – as only Harrison’s can cover it Featuring a superb compilation of chapters related to infectious diseases that appear in Harrison’s Principles of Internal Medicine, Eighteenth Edition, this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s. You will find content from renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation. Features Current, complete coverage of need-to-know topics, including infections in organ systems, bacterial infections, viral infections, prion diseases, fungal infections, and protozoal infections Addresses underlying epidemiologic, pathophysiologic, and genetic factors Important material on HIV infections and AIDS by Anthony S. Fauci and H. Clifford Lane Two image-based chapters comprise atlases valuable to clinical assessment: rashes associated with fever and blood smears of the various stages of the parasites causing malaria and babesiosis Integration of pathophysiology with clinical management 121 high-yield questions and answers drawn from Harrison’s Principles of Internal Medicine Self-Assessment and Board Review, 18e Content updates and new developments since the publication of Harrison’s Principles of Internal Medicine, 18e 132 chapters written by physicians who are recognized experts in the field of infectious diseases Helpful appendix of laboratory values of clinical importance

Anthony Fauci

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