M. Iqbal Choudhary

Atta-ur-Rahman

Frontiers in Anti-Cancer Drug Discovery is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery, including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The Ebook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery. The Ebook series is essential reading for all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

Frontiers in Anti-Cancer Drug Discovery

Natural Product Chemistry continues to expand to exciting new frontiers of great importance in medicine. Written by international authorities in various fields of natural product chemistry, this latest volume in the well-established series Studies in Natural Products Chemistry contains 23 chapters, covering topics ranging from immunosuppressant and antimalarial compounds to bioactive substances useful in cancer and neural diseases. This present volume, will again be of great interest to research scientists and scholars working in the exciting field of new drug discovery.* Written by international authorities in the various fields of natural product chemistry* Contains 23 comprehensive articles covering topics ranging from immunosuppressant and antimalarial compounds to bioactive substances useful in cancer and neural diseases* Valuable source of information for research scientists and scholars in the field of new drug discovery.

Bioactive Natural Products (Part P)

Studies in Natural Products Chemistry

Sammer Yousuf

Many herbs and spices, in addition to their culinary use for taste, contain chemical compounds which have medicinal uses. For this reason, herbs and spices have been used for treating various ailments since ancient times. Modern scientific methods have enabled researchers to isolate bioactive compounds from herbs and spices and perform chemical analyses, which can be used to develop medicines to treat different diseases. This book series is a compilation of current reviews on studies performed on herbs and spices. Science of Spices and Culinary Herbs is essential reading for medicinal chemists, herbalists and biomedical researchers interested in the science of natural herbs and spices that are a common part of regional diets and folk medicine. The fourth volume of this series features the following reviews: 1. Pharmacological effects of Curcuma longa, focused on anti-inflammatory, antioxidant and immunomodulatory effects 2. Ethnomedicinal uses, Phytochemistry, Pharmacological effects, Pre-clinical and Clinical studies on flaxseed: A spice and culinary herb-based formulations and its constituents 3. Nigella sativa (Prophetic medicine): The Miracle Herb 4. Properties of Mexican oregano (Lippia spp.) essential oils and their use in aquaculture 5. Curry leaf: An insight into its Pharmacological activities, Medicinal profile, and Phytochemistry

Science of Spices and Culinary Herbs - Latest Laboratory, Pre-clinical, and Clinical Studies

Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The ninth volume of the series features chapters covering the following topics: - New research on the therapeutic intervention of cancer and cancer drug delivery - Dabrafenib usage in melanoma therapy - Targeting autophagy in cancer therapy - Pro-apoptotic and anti-telomerase activity of naturally occurring compounds - CDK inhibitors - Oral nanostructure drug delivery for anti-cancer treatment

Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series. The sixth volume of the series brings seven reviews covering these topics: -Inhibition of monoamine oxidase (MAO) via green tea extracts -Sesquiterpene lactone cynaropicrin as novel inhibitor of Bcr-Abl fusion oncogene expression -Effects of dietary polyphenols on chronic diseases -Overview of past and present developments towards biotechnological and molecular approaches to improve taxol production -Cytotoxicity through molecular targets involved in apoptosis -Health related enzyme inhibiting natural products from medicinal plants

Frontiers in Natural Product Chemistry: Volume 5

Frontiers in Clinical Drug Research - Anti-Cancer Agents is an eBook series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology researchers. The third volume of the eBook series begins with a detailed review of the molecular biology of inhibitors that target EGF-family receptors. This review is divided into two parts that covers extracellular and intracellular molecules. Other reviews cover targeted therapies for cancers such as melanoma, follicular lymphoma and topics such as cancer immunotherapy, apoptosis targeting and the Warburg Effect.

Frontiers in Clinical Drug Research - Anti-Cancer Agents

 Muhammad Iqbal Choudhary

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, and wound healing disorders. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians. The fifth volume brings together reviews on the following topics: - Targeted therapy for tumor vasculature - Anti-angiogenic therapy for breast and prostate cancers (including information updates on clinical trials) - Microbe-based and other novel antiangiogenesis therapies such as chromene-based agents

Anti-Angiogenesis Drug Discovery and Development: Volume 5

George Perry

Muhammad Iqbal Choudhary

Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more. Edited and written by leading experts in medicinal chemistry research Reviews recent advances in the field, including the characterization of inorganic nanomaterials as therapeutic vehicles Covers a variety of topical areas, such as HPLC and in the analysis of tricyclic antidepressants in biological samples, and tannins and their influence on health

Recent Advances in Medicinal Chemistry

Allen B. Reitz

Frontiers in Medicinal Chemistry is an E-book series devoted to reviews on research topics relevant to medicinal chemistry and allied disciplines. Frontiers in Medicinal Chemistry covers developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships. This E-book series is essential for any medicinal chemist who wishes to be updated on the latest and the most important advances in the field. This volume features reviews on the following topics: • Purinergic receptors and pain • Cytochrome c – cardiolipin interactions in cells • Dipeptidyl peptidase-4 (CD26) functions and inhibition • Peptides regulating angiogenesis • Application of melanotropin ligands for the treatment of obesity and related disorders • Targeted drugs in the field of nanomedicine

Frontiers in Medicinal Chemistry

This volume presents frontier reviews on recent developments on bioactive natural products in cutting-edge areas by eminent experts in their respective fields. Fourteen reviews treat diverse and different topics in natural products chemistry - basic ones, medicinally oriented ones, agro-oriented ones and ecologically oriented ones. It is an important addition to this important series on Natural Products Chemistry, generally acknowledged to be the leading series on this topic.

Frontiers in Natural Product Chemistry is an Ebook series devoted to publishing monographs that highlight important advances in natural product chemistry. The Ebook series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds including coverage of work on natural substances of land and sea and of plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are included. The second volume of the series brings seven reviews covering polyphenols of various types, Sambucus nigra as a health promoter, corrinoids in food samples, flavonoids in infected plants and much more.

Frontiers in Natural Product Chemistry

Natural Products Chemistry continues to grow at an increasing pace and this growth is reflected in the present volume of Studies in Natural Products Chemistry, which is the 20th of this series. The first 20 volumes were largely devoted to structure and synthesis of various classes of natural products, irrespective of their bioactivity. Subsequent volumes of this series will however be devoted to the chemistry of bioactive natural products and will therefore a departure from the earlier volumes. The present volume contains contributions from a number of eminent scientists and covers interesting reviews on terpenes, alkaloids and other types of natural products reported from terrestrial and marine sources. Comprehensive indexes covering all the 20 volumes have been prepared which include a Cumulative General Subject Index along with more focused Cumulative Indices on Organic Synthesis, Pharmacological Activity and Biological Source. This comprehensive indexing of the volumes should make the entire series much more valuable and user-friendly.

Structure and Chemistry (Part F)

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. The third volume of this series features six chapters that cover a variety of topics including: -the role of Potassium transport channels in neuroprotection against tetrahydroprotoberberines -cannabinoids in cell therapy for CNS disorders -AMPA Receptor Antagonists -therapeutic intervention in polyglutamine ataxias -nutritional therapies in neurology practice

CNS and Neurological Disorders

Frontiers in Clinical Drug Research - Hematology is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of hematological disorders. The scope of the eBo

Frontiers in Clinical Drug Research: Hematology

“Frontiers in CNS Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to all pharmaceutical scientists involved in research in CNS drug design and discovery. Each volume is devoted to the major advances in CNS drug design and discovery. The eBook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

Frontiers in CNS Drug Discovery

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians. This volume brings together 5 reviews on these topics: -Beta-blockers for treating premature retinopathy -Anti-angiogenic activity of disintegrin-based, synthetic cyclic KTS peptides -Anti-angiogenic therapy of lung cancer -Oral anti-angiogenic therapy for NSCLC -Angiogenesis in hepatocellular carcinoma

Anti-Angiogenesis Drug Discovery and Development

Studies in Natural Products Chemistry Volume 12: Stereoselective Synthesis (Part H) reviews the stereoselective synthetic and mechanistic chemistry of bicyclomycin. It discusses chemical studies of the taxane diterpenes; the synthetic methodology for 2-amino alcohols of biological interest; and the synthesis and structure of hydroxylated indolizidines. Some of the topics covered in the book are the synthetic routes to the oxahydrindene subunit of the avermectin-milbemycin family of antiparasitic agents; isolation, structure elucidation, biosynthesis, and biological activity of the avermectins; two-stage coupling process of macrolide antibiotics synthesis; and synthesis of the rifamycin S ansa-chain compound. The complete synthesis of erythromycin A is also covered. The role of isocyanides in the synthesis of beta lactam antibiotics and the characteristics of the beta lactam antibiotics are discussed. The development of an A-Ring annulation strategy for taxane synthesis is also presented. A chapter is devoted to the advances in the synthesis of tumor-promoting diterpenes. The book can provide useful information to chemists, biologists, students, and researchers.

Stereoselective Synthesis

Bioactive Natural Products (Part G)

Sibel Ozkan

Recent Advances in Analytical Techniques is a series of updates in techniques used in chemical analysis. Each volume presents a selection of chapters that explain different analytical techniques and their use in applied research. Readers will find updated information about developments in analytical methods such as chromatography, electrochemistry, optical sensor arrays for pharmaceutical and biomedical analysis. The fifth volume of the series features five reviews which demonstrate chemical analysis techniques applied in different disciplines. - Superior Aspects of Liquid Chromatography-Based Mass Spectrometers in Chiral Analysis - New Trends in Sample Preparation for Pharmaceutical and Biological Analysis by Chromatographic Methods - Qualitative and Quantitative Investigation of Bio Tissues using Microscopy and Data Mining - Analytical Techniques For Analysis of Metals and Minerals in The Soil Samples - Monitoring Therapeutic Response in Cancers: A Raman Spectroscopy Approach

Recent Advances in Analytical Techniques: Volume 5

Shazia Anjum

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as tumors, Alzheimer’s disease and related neurodegenerative diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. The second volume of this series features reviews on several key topics in this field including cardiac regeneration strategies, induced pluripotent stem cell therapeutics, stem cell therapy for peripheral nerve and cutaneous injuries, dental tissue regeneration, the potential of stem cell differentiation into ovarian cells and much more.

Atta-ur-Rahman

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