Stanley G. Schultz

Brenda B. Rauner

American Physiological Society (1887- )

The Gastrointestinal System

Gabriel M. Makhlouf

This volume marks the coming of age of knowledge concerning the neural and endocrine biology of the gut. It is the first volume in the Handbook of Physiology to be devoted entirely to this field. It is also the very first volume ever published that deals systematically with the biochemistry, cell biology, molecular biology, pharmacology, and physiology of hormonal and neural peptides of the gut. Written by some forty recognized experts, Neural and Endocrine Biology details the discoveries of a field that is now just twenty-five years old. The early chapters address general topics and provide a broad overview of the field, including information on immunocytochemistry of endocrine cells and enteric neurons and the physiological significance of hormonal, paracrine, and neural peptides. Fourteen of the volume's twenty-eight chapters are devoted to individual hormonal and neural peptides--their distribution, pharmacology, and physiological and cellular functions. The final chapter offers an overview of recently discovered peptides, including pancreastatin and two neural peptides, galanin and calcitonin gene-related peptide (CGRP). Neural and Endocrine Biology will be a welcome new resource for graduate students, instructors, and active researchers and clinicians who need a complete, up-to-date reference in regulatory peptides and gastrointestinal physiology and pharmacology.

Neural and Endocrine Biology

Michael Field

Raymond A. Frizzell

Here is a thorough, up-to-date survey of the physiological processes through which salt, water, and nutrients are absorbed or secreted by the intestinal tract, and of how these myriad processes are regulated. In twenty-five chapters, written by a team of leading experts, the volume addresses four main topics: the methodologies and basic principles of structure and function; intestinal ion transport; nutrient absorption; and macromolecular transport. Throughout, the contributors emphasize recent developments in the field--for example, neuroendocrine-immune cell interactions in the intestinal mucosa, the regulation of intestinal sodium transport, the cloning of the intestinal glucose carrier, the intestinal cytoskeleton, and the regulation of intestinal epithelial transport function by protein kinases and calmodulin. This is not only the fourth and final volume in the series; it is also the broadest, most contemporary approach to this important topic. As such, this book will be warmly welcomed--and often consulted--by student, scholars, professionals, and anyone researching intestinal absorptive mechanisms and their regulation.

Brenda B. Rauner

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