Bruce L. Miller

Jeffrey L. Cummings

Now in a revised and expanded second edition, this authoritative work synthesizes the rapidly growing knowledge base on the human frontal lobes and their central role in behavior, cognition, health, and disease. Leading contributors address neuroanatomy, neurochemistry, and normal neuropsychological functioning, and describe the nature and consequences of frontal lobe dysfunction in specific neurological and psychiatric conditions. Second edition features include a new section on structural and functional neuroimaging and substantially expanded coverage of frontotemporal dementia and related disorders. Other new topics include self-consciousness, competence, and personality; new testing approaches; bipolar disorder; and adult-onset genetic disorders of the frontal lobes. The book is illustrated with nearly 100 figures.

Functions and Disorders

The Human Frontal Lobes, Second Edition

Indre V. Viskontas

In this special issue, leading neuroscientists and neurologists present comprehensive review papers and empirical studies on the topic of the neural basis of self-identification. From philosophical definitions to single-case studies, the articles provide the reader with a broad view of the self in contemporary neuroscience. Review papers address the fundamental question of how to define and study the construct of identity. Methods in empirical studies range from socio-linguistic analyses to neuroimaging and diverse patient populations. As a whole, this issue provides a diverse sample of the myriad of ways in which identity is defined and studied in contemporary neuroscience.

A Special Issue of Neurocase

Elucidating the Neural Basis of the Self

"Subject Areas/Keywords: brains, cognitive, diseases, dysfunctions, executive functions, frontal-subcortical circuits, frontotemporal dementia, human frontal lobes, lesions, mental disorders, networks, neuroanatomy, neurological, neurology, neuronal pathways, neuropsychiatric disorders, neuropsychological assessments, neuropsychology, neuroscience, normal aging, prefrontal cortex DESCRIPTION This authoritative work, now thoroughly revised, has given thousands of clinicians, students, and researchers a state-of-the-art understanding of the human frontal lobes--the large brain region that plays a critical role in behavior, cognition, health, and disease. Leading authorities from multiple disciplines address the anatomy and chemistry of the frontal cortex, neuropsychological assessments of capabilities unique to the frontal lobes, the nature of (and possible treatment avenues for) frontotemporal dementia and related conditions, and implications for understanding and treating neuropsychiatric disorders, such as schizophrenia, mania, and depression. Illustrations include eight pages in full color"--

The Human Frontal Lobes, Third Edition

Thomas Lehner

Matthew W. State

This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry

Bradley F. Boeve

The Behavioral Neurology of Dementia is a comprehensive textbook that offers a unique and modern approach to the diagnosis and treatment of patients with dementing conditions in the twenty-first century. The coverage is broad, ranging from common conditions such as Alzheimer's disease, Parkinsonian disorders, vascular and frontotemporal dementia, to the more obscure such as Creutzfeldt–Jakob disease. Subtypes of mild cognitive impairment are presented and the early prodromes of neurodegenerative diseases are explored. Simple approaches to bedside mental status testing, differential diagnosis and treatment, genetic testing, interpreting neuropsychological testing and neuroimaging findings, and assessing rapidly progressive dementias, paraneoplastic syndromes and disorders of white matter give guidance to both the novice and expert in dementia. The basic science of dementia is outlined in introductory chapters on animal models of dementia, dementia epidemiology and dementia neuropathology.

Bruce L. Miller

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