Carlo Sala

Chiara Verpelli

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. - Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities - Describes the genes implicated in autistic spectrum disorders and their function - Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies - Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Menahem Segal

Martine Ammassari-Teule

Dendritic Spines: from Biophysics to Neuropathology

Michael R. Kreutz

This book introduces the current concepts of molecular mechanisms in synaptic plasticity and provides a comprehensive overview of cutting-edge research technology used to investigate the molecular dynamics of the synapses. It explores current concepts on activity-dependent remodeling of the synaptic cytoskeleton and presents the latest ideas on the different forms of plasticity in synapses and dendrites. Synaptic Plasticity in Health and Disease not only supplies readers with extensive knowledge on the latest developments in research, but also with important information on clinical and applied aspects. Changes in spine synapses in different brain disease states, so-called synaptopathies, are explained and described by experts in the field. By outlining basic research findings as well as physiological and pathophysiological impacts on synaptic plasticity, the book represents an essential state-of-the-art work for scientists in the fields of biochemistry, molecular biology and the neurosciences, as well as for doctors in neurology and psychiatry alike.

Dynamics, Development and Disease

Synaptic Plasticity

Maria Grazia Ciani

Piermario Vescovo

Barbara Baert

Monica Centanni

Andrea Torre

Maddalena Bassani

Mario Cesarano

Gabriella Fényes

Simona Dolari

Lorenzo Gigante

Elena Pirazzoli

Editoriale a cura di Maddalena Bassani, Alessandra Pedersoli Maria Grazia Ciani, Voci dal fondo. Danae nelle testimonianze dell’antichità greco-latina Monica Centanni, Il nome dei Persiani. Δαναής τε γόνου / τὸ παρωνύμιον γένος ἡμέτερον (Aesch. Pers., 144-145, ed. West) Mario Cesarano, Danae, Perseo e Acrisio tra gli Etruschi di Spina Maddalena Bassani, Danae fondatrice di Ardea. Note per una ricerca Gabriella Fényes, A Terracotta Mould from Aquincum depicting the Story of Danaë Andrea Torre, Le Danae di Petrarca (e non solo) Piermario Vescovo, “Ella si siede sola sopra un scanno; io mi vo’ tramutare in pioggia d’oro”. Note sulla Comedia de Danae di Baldassarre Taccone Barbara Baert, Oculi! Danaë and the Uncanny Space Simona Dolari, “Titian. Love, Desire, Death”. Recensione alla mostra della National Gallery di Londra (16 Marzo 2020 – 17 Gennaio 2021) Lorenzo Gigante, Da Tiziano a Bellucci, da Danae a Danae. Dialogo con un dipinto problematico Elena Pirazzoli, ”In questa cassa piena di chiodi”. La Danae di Tiziano da Montecassino a Carinhall, da Altaussee alla Farnesina Carlo Sala, La Danaë di Vadim Zakharov alla Biennale 2013. Un’allegoria del sistema economico e mediatico internazionale

e178 | Danae. Bagliori del mito

Carlo Sala

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