Cold Spring Harbor Laboratory

Annual Report

Eukaryotic Viral Vectors

So much has been learned about the surface of cells that it can almost be counted as an organelle. The surface has been revealed as a complex assembly of proteins, highly mobile in time and space, with overlapping activities and shared structural motifs. The locations of their genes and the untangling of their functions are major challenges being tackled by laboratories worldwide. The 57th annual Cold Spring Harbor Symposium brought together over 80 leading investigators to discuss data and ideas on receptor-ligand interactions, membrane organization, signal transduction, peptide transport, cell adhesion, and the regulation of developmental processes. Studies in molecular and cell biology, embryology, neurobiology, and immunology were presented. This volume of collected papers from the Symposium, like its predecessors in this most prestigious series, provides a wide-ranging, eclectic review of a topic central to the understanding of cell structure and function

The Cell Surface

Movable Genetic Elements

Bruce Stillman

Proceedings of a summer 1998 meeting, presenting results of recent studies in gene transcription. Covers events ranging from activation, through promoter recognition, repression, chromosome structure, chromatin remodeling, initiation and elongation, and regulatory complexes and pathways. Subjects include targeting sir proteins to sites of action, the yeast RNA polymerase III transcription machinery, nuclear matrix attachment regions to confer long-range function on immunoglobulin, ATP-dependent remodeling of chromatin, and the transcriptional basis of steroid physiology. Annotation copyrighted by Book News, Inc., Portland, OR.

Mechanisms of Transcription

The architecture of an embryo results from complex molecular interactions in time and space. The secrets of these processes are yielding quickly to genetic and cellular dissection in flies, mice and other species, and finding application to human embryology. This volume presents a survey of the induction of axes, control of cell migration, and the development of the nervous system, limbs, wings and other organs, seen from the perspective of 61 investigators. It is completed by a summary that charts the future of this dynamic field.

Cold Spring Harbor Laboratory

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