Csaba Szabo

Gyorgy Hasko

Bruce N. Cronstein

After a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the development of compounds that interfere with the breakdown of adenosine, as well as specific agonists and antagonists of various adenosine subtypes. Some of these compounds have already entered clinical trials. While information on the role of adenosine is growing rapidly, until now it has remained scattered in the literature. Edited by three pioneering researchers in the field, Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases presents the first single volume compilation of reviews on how adenosine, acting on its cellular receptors, regulates immune responses. The book is organized to provide the reader with a general overview of adenosine receptors, delving into molecular biology, cell biology, and pharmacology. Separate chapters focus on the role of adenosine receptors in regulating the function of the various cell types that are involved in immune responses. Further chapters delineate the role of purinergic signaling in the pathophysiology of a variety of disease states associated with an overzealous or insufficient immune response. These include autoimmune diseases, asthma, atherosclerosis, ischemia-reperfusion injury, and cancer. Much of the methodology and findings documented in this text may well lead to new therapeutic modalities for pathologies such as ischemia and reperfusion, heart disease, wound healing, tumors, pain, and a variety of central nervous system diseases including Parkinson’s, Alzheimer’s, and epilepsy, as well as mood and sleep disorders. This resource provides background and direction for those researchers entering the field of adenosine and inflammatory disease, and provides a comprehensive reference for experienced investigators.

Therapeutic Aspects for Inflammatory and Immune Diseases

Adenosine Receptors

This volume focusses on the life and academic heritage of András Bodor (1915-1999), a classicist from Transylvania. Based on a large number of unpublished documents and the major works of Bodor, the book reconstructs the life of a classicist from the periphery of Europe, a region that changed many times during the 20th century.

András Bodor and the History of Classical Studies in Transylvania in the 20th century

This book focuses on lived ancient religious communication in Roman Dacia. Testing for the first time the ‘Lived Ancient Religion’ approach in terms of a peripheral province from the Danubian area, this work looks at the role of ‘sacralised’ spaces, known commonly as sanctuaries in the religious communication of the province.

Materiality and Religious Experience

Sanctuaries in Roman Dacia

Imrich Chlamtac

Ashwin Gumaste

Access to the Internet is an increasing problem in many areas of the world. As the popularity and usefulness of the Internet increases on a daily basis, lack of access to the technology is putting many groups at a disadvantage in terms of better education, better jobs and even in terms of higher levels of civic participation. However, creating a network infrastructure to serve outlying communities and sectors of the population is not straight-forward. This book brings together all the aspects of the problem – technical, regulatory and economic - into one volume to provide a comprehensive resource. It describes the latest technological advances that allow cost-effective network infrastructures to be built, and places them in the context of the applications and services that the infrastructure will deliver. A section on business models and case studies from North American and Europe demonstrate that the solutions are economically and practically viable. This book is essential for anyone looking to gain an understanding of the issues and technology surrounding the access debate. It will be of particular relevance to network engineers/designers/planners at the incumbent operator companies charged with delivering broadband access to as yet unconnected regions. Governments and regulatory bodies will also find this a useful guide to the problems that they may face.

Csaba Szabo

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