Philip O'Connor

David A. Isenberg

Philip G. Conaghan

This handbook provides a comprehensive insight into how imaging techniques should be applied to particular clinical problems and how the results can be used to determine the diagnosis and management of musculoskeletal conditions.

Musculoskeletal Imaging

Presents an analysis of the importance of this group of disorders during adolescence and offers a guide for the physicians who care for this patient group.

Adolescent Rheumatology

Diseases of the joints and surrounding tissues cannot be visualised without the help of imaging techniques. These range from x-rays (which have been available for over 100 years) to the highly sophisticated magnetic resonance imaging scanning. The variety of imaging techniques and indeed the quality of these images has improved radically in the past decade and this book attempts to capture the way in which rheumatologists and their colleagues can use a wide variety of techniques to analyse musculoskeletal diseases which are known to exist. This handbook provides the reader with an insight into both which imaging techniques should be applied to particular clinical problems and how the results can be used to determine the diagnosis and management of musculoskeletal conditions. It is extensively illustrated with examples of the various imaging techniques and joints to aid understanding, and is organised by anatomical region and specific musculoskeletal disorder to allow easy access to information.

Yehuda Shoenfeld

Natural Autoantibodies provides an in-depth analysis of all aspects of natural antibodies. The book examines the advantages and pitfalls of every type of technique that is widely used for detecting autoantibodies. It also covers the sequencing of human autoantibody genes, discussing how sequencing is undertaken and the genetic clues available to elucidate the genetic origins of autoimmunity. Animal models of autoimmunity are also covered, and the up-to-date account provided in this book explains how natural autoantibodies have important regulatory functions and also occasionally serve as templates for autoimmunity. Other topics examined in Natural Autoantibodies: Their Physiological Role and Regulatory Significance include idiotypes of natural autoantibodies; the pathogenic role of natural autoantibodies; and methods to measure the effects of genetic and sex hormones, as well as aging, on natural autoantibodies. The book will be an excellent research tool and reference for immunologists, rheumatologists, and others interested in the topic.

David A. Isenberg

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