Esteban A. Hernandez-Vargas

Fabian Theis

Lars Kaderali

Vitaly V. Ganusov

Stanca M. Ciupe

Ramit Mehr

Ruy Ribeiro

Integrative Computational Systems Biology Approaches in Immunology and Medicine

Modeling and Control of Infectious Diseases in the Host: With MATLAB and R provides a holistic understanding of health and disease by presenting topics on quantitative decision-making that influence the development of drugs. The book presents modeling advances in different viral infections, dissecting detailed contributions of key players, along with their respective interactions. By combining tailored in vivo experiments and mathematical modeling approaches, the book clarifies the relative contributions of different underlying mechanisms within hosts of the most lethal viral infections, including HIV, influenza and Ebola. Illustrative examples for parameter fitting, modeling and control applications are explained using MATLAB and R. Provides a multi-scale framework to link within-host infection dynamics (individual level) to between-host transmission fitness (epidemiological level) in viral infectious diseases Includes PK/PD modeling and simulation approaches to improve efficiency and decision-making at preclinical development phases Presents a theoretic approach to schedule drug treatments

With MATLAB and R

Modeling and Control of Infectious Diseases in the Host

Esteban A. Hernandez-Vargas

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