Dingzhu Du

Frank Hwang

Pooling designs have been widely used in various aspects of DNA sequencing. In biological applications, the well-studied mathematical problem called "group testing" shifts its focus to nonadaptive algorithms while the focus of traditional group testing is on sequential algorithms. Biological applications also bring forth new models not previously considered, such as the error-tolerant model, the complex model, and the inhibitor model. This book is the first attempt to collect all the significant research on pooling designs in one convenient place.The coverage includes many real biological applications such as clone library screening, contig sequencing, exon boundary finding and protein-protein interaction detecting and introduces the mathematics behind it.

Important Tools for DNA Sequencing

Pooling Designs and Nonadaptive Group Testing

This book is a collection of surveys and exploratory articles about recent developments in the field of computational Euclidean geometry. The topics covered are: a history of Euclidean geometry, Voronoi diagrams, randomized geometric algorithms, computational algebra; triangulations, machine proofs, topological designs, finite-element mesh, computer-aided geometric designs and steiner trees. Each chapter is written by a leading expert in the field and together they provide a clear and authoritative picture of what computational Euclidean geometry is and the direction in which research is going.

Frank Hwang

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