Mostafa Bachar

Jerry J. Batzel

Franz Kappel

This volume synthesizes theoretical and practical aspects of both the mathematical and life science viewpoints needed for modeling of the cardiovascular-respiratory system specifically and physiological systems generally. Theoretical points include model design, model complexity and validation in the light of available data, as well as control theory approaches to feedback delay and Kalman filter applications to parameter identification. State of the art approaches using parameter sensitivity are discussed for enhancing model identifiability through joint analysis of model structure and data. Practical examples illustrate model development at various levels of complexity based on given physiological information. The sensitivity-based approaches for examining model identifiability are illustrated by means of specific modeling examples. The themes presented address the current problem of patient-specific model adaptation in the clinical setting, where data is typically limited.

Applications to the Cardiovascular and Respiratory Systems

Mathematical Modeling and Validation in Physiology

Karl Kunisch

Wolfgang Desch

22 papers on control of nonlinear partial differential equations highlight the area from a broad variety of viewpoints. They comprise theoretical considerations such as optimality conditions, relaxation, or stabilizability theorems, as well as the development and evaluation of new algorithms. A significant part of the volume is devoted to applications in engineering, continuum mechanics and population biology.

International Conference in Vorau (Austria), July 18–24, 1993

Control and Estimation of Distributed Parameter Systems: Nonlinear Phenomena

Kazufumi Ito

This book presents an approximation theory for a general class of nonlinear evolution equations in Banach spaces and the semigroup theory, including the linear (Hille–Yosida), nonlinear (Crandall–Liggett) and time-dependent (Crandall–Pazy) theorems. The implicit finite difference method of Euler is shown to generate a sequence convergent to the unique integral solution of evolution equations of the maximal monotone type. Moreover, the Chernoff theory provides a sufficient condition for consistent and stable time integration of time-dependent nonlinear equations. The Trotter–Kato theorem and the Lie–Trotter type product formula give a mathematical framework for the convergence analysis of numerical approximations of solutions to a general class of partial differential equations. This book contains examples demonstrating the applicability of the generation as well as the approximation theory. In addition, the Kobayashi–Oharu approach of locally quasi-dissipative operators is discussed for homogeneous as well as nonhomogeneous equations. Applications to the delay differential equations, Navier–Stokes equation and scalar conservation equation are given. Contents: Dissipative and Maximal Monotone OperatorsLinear SemigroupsAnalytic SemigroupsApproximation of C0-SemigroupsNonlinear Semigroups of ContractionsLocally Quasi-Dissipative Evolution EquationsThe Crandall–Pazy ClassVariational Formulations and Gelfand TriplesApplications to Concrete SystemsApproximation of Solutions for Evolution EquationsSemilinear Evolution EquationsAppendices:Some InequalitiesConvergence of Steklov MeansSome Technical Results Needed in Section 9.2 Readership: Researchers in the fields of analysis & differential equations and approximation theory. Keywords:Evolution Equations;Approximations;Euler;Trotter-Kato;Lie-Trotter;Quasi-Dissipative Operators;K and Y Kobayashi;S OharuReviews:“Ito and Kappel offer a unified presentation of the general approach for well-posedness results using abstract evolution equations, drawing from and modifying the work of K and Y Kobayashi and S Oharu … their work is not a textbook, but they explain how instructors can use various sections, or combinations of them, as a foundation for a range of courses.”Book News, Inc.

Evolution Equations And Approximations

Daniel Schneditz

Hien T. Tran

Cardiovascular and Respiratory Systems: Modeling, Analysis, and Control uses a principle-based modeling approach and analysis of feedback control regulation to elucidate the physiological relationships. Models are arranged around specific questions or conditions, such as exercise or sleep transition, and are generally based on physiological mechanisms rather than on formal descriptions of input-output behavior. The authors ask open questions relevant to medical and clinical applications and clarify underlying themes of physiological control organization. Current problems, key issues, developing trends, and unresolved questions are highlighted. Researchers and graduate students in mathematical biology and biomedical engineering will find this book useful. It will also appeal to researchers in the physiological and life sciences who are interested in mathematical modeling.

Franz Kappel

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