Guillaume Fertin

Anthony Labarre

Irena Rusu

Stéphane Vialette

Eric Tannier

A comprehensive survey of a rapidly expanding field of combinatorial optimization, mathematically oriented but offering biological explanations when required. From one cell to another, from one individual to another, and from one species to another, the content of DNA molecules is often similar. The organization of these molecules, however, differs dramatically, and the mutations that affect this organization are known as genome rearrangements. Combinatorial methods are used to reconstruct putative rearrangement scenarios in order to explain the evolutionary history of a set of species, often formalizing the evolutionary events that can explain the multiple combinations of observed genomes as combinatorial optimization problems. This book offers the first comprehensive survey of this rapidly expanding application of combinatorial optimization. It can be used as a reference for experienced researchers or as an introductory text for a broader audience. Genome rearrangement problems have proved so interesting from a combinatorial point of view that the field now belongs as much to mathematics as to biology. This book takes a mathematically oriented approach, but provides biological background when necessary. It presents a series of models, beginning with the simplest (which is progressively extended by dropping restrictions), each constructing a genome rearrangement problem. The book also discusses an important generalization of the basic problem known as the median problem, surveys attempts to reconstruct the relationships between genomes with phylogenetic trees, and offers a collection of summaries and appendixes with useful additional information.

Combinatorics of Genome Rearrangements

Giancarlo Mauri

Riccardo Dondi

This volume constitutes the proceedings of the 11th International Conference on Algorithmic Aspects in Information and Management, AAIM 2016, held in Bergamo, Italy, in July 2016. The 18 revised full papers presented were carefully reviewed and selected from 41 submissions. The papers deal with current trends of research on algorithms, data structures, operation research, combinatorial optimization and their applications.

11th International Conference, AAIM 2016, Bergamo, Italy, July 18-20, 2016, Proceedings

Algorithmic Aspects in Information and Management

Guillaume Fertin

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