Howard I. Maibach

Robert Baran

This text documents the science that lies behind the expanding field of cosmetic dermatology so that clinicians can practice with confidence and researchers can be fully aware of the clinical implications of their work. New chapters have been added to this edition on photodamage, actinic keratoses, UV lamps, hidradenitis suppurativa, age-related changes in male skin, changes in female hair with aging, nonabltaive laser rejuvenation, and cryolipolysis, and chapters have been updated throughout to keep this at the forefront of work and practice. The Series in Cosmetic and Laser Therapy is published in association with the Journal of Cosmetic and Laser Therapy. Print Versions of this book also include access to the ebook version.

Textbook of Cosmetic Dermatology

Robert N. Phalen

This revised edition discusses ever-growing importance of protective gloves to occupation health in a single volume. It will an ideal text for professionals and graduate students in the fields of occupational and industrial hygiene, health care, chemical engineering, pharmacy, and environmental health.

Protective Gloves for Occupational Use

Robert L. Bronaugh

In Vitro Percutaneous Absorption covers all major areas of interest in the rapidly expanding field of in vitro methods for percutaneous absorption studies. Specific areas discussed include diffusion cell design, receptor fluid, preparation of skin, and temperature. The book covers experimental methodology, as well as the underlying principles and fundamentals that help professionals and students gain an understanding of the basis for currently used methodology.

Principles, Fundamentals, and Applications

In Vitro Percutaneous Absorption

Toxic injury to the skin in the general population, and particularly in western populations, is on the increase. This is partly due to the expanding number of natural and man-made chemicals present in our everyday environment. The need for a thorough understanding of the skin, and the mechanisms of toxicity therein, has never been more pressing. Th

Toxicology of Skin

Peter Elsner

Enzo Berardesca

This book focuses on the objective measurement of two major parameters of skin function: blood flow and erythema.

Cutaneous Blood Flow and Erythema

Bioengineering of the Skin

Doris Schwindt

Biometrics in dermatology is an essential tool where data evaluation results in valid interpretations. This book will be the first in this area. One part of the book will describe principal aspects of dermatological research focussing on practical advice. A special part will cover applied biometrics to provide the clinician and researcher with state-of-the-art guidelines to assess the severity of common skin diseases. An additional aspect that will be of interest to pharmacologists addresses pharmacologic assays.

Cutaneous Biometrics

Torkil Menne

Exogenous Dermatoses presents a collection of comprehensive essays written by experts scientifically active in exogenous dermatoses research. Main areas covered include basic biological mechanisms, diagnostic methods, experimental investigations, and clinical aspects. The book will be an important source of reference for clinical and experimental dermatologists and scientists working with skin immunology and toxicology. It will also provide important information for cosmetic and pharmaceutical research.

Environmental Dermatitis

Exogenous Dermatoses

Hongbo Zhai

Klaus Peter Wilhelm

The foundational reference in dermal toxicology, this classic text has been completely revised to bring it up to date in the new Eighth Edition, with almost a third of its chapters being newly added. The structure of the text has also been reorganized to enable easier location of a topic of interest. With contributions from leading international experts, this continues the tradition of providing unsurpassed theoretical and practical guidance for all those working on research aspects, on practical clinical issues, and on the regulatory aspects of exposure to toxic substances. This new edition contains updates to each chapter and contributions from leading international experts, provides an in-depth summary of research and regulatory applications related to dermal toxicology and pharmacology, presents many new chapters that describe the latest advances in dermatotoxicology, and addresses various levels of expertise regarding the development and use of dermal exposure data. New chapters include those on safety terminology, pharmacogenetics and dermatology, ethnic differences in skin properties, and the principles and practice of percutaneous absorption.

Dermatotoxicology, Eighth Edition

Andreas J. Bircher

Knut Brockow

Annick Barbaud

This book covers all aspects of hypersensitivity to drugs, providing practical information for non-specialist physicians as well as addressing issues of interest to practitioners in different specialties and presenting the expert knowledge required by specialist allergists and immunologists. The opening, general section discusses basics such as clinical manifestations, histopathology, mechanisms, risk factors, drug hypersensitivity in particular populations, and the full range of diagnostic methods. The second part of the book provides concise information on the most important drug classes and guides the reader on how to proceed when patients present with a suspected reaction. For each drug class, the current level of evidence for use of the different diagnostic tools, including skin tests, provocation tests, and in vitro tests, is clarified, and management options, outlined. The inclusion of helpful tables and algorithms is designed to aid in decision making. Drug hypersensitivity is among the more complex allergological issues, and this book will meet the needs of general practitioners, internists, and specialists.

Clinical Features, Mechanisms, Diagnosis, and Management

Cutaneous Drug Hypersensitivity

Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.

Drugs--Cosmetics--Mechanisms--Methodology: Drugs--Cosmetics--Mechanisms--Methodology, Third Edition,

Percutaneous Absorption

Marie Lodén

Development of moisturizers is a scientific and artistic discipline, where consumer insights are also needed. This new book bridges the gap between the moisturizers and the skin by covering all the essential information required to tailor the use of moisturizers to particular disorders and patients. Important aspects of skin biochemistry and barrier function are explained, and the ingredients and treatment effects of moisturizers are explored in depth. Careful attention is paid to controversies, including the role of certain moisturizers in inducing dryness/eczema, asthma, and comedones. The information provided in this unique book will enable the reader to go beyond the traditional thinking regarding skin care. The novel insights offered will suggest the properties required for a new generation of moisturizing treatments that more effectively improve the quality of life.

The Art and Science of Moisturizers

Treatment of Dry Skin Syndrome

Joachim W. Fluhr

Bioengineering of the skin, or more precisely the biophysical assessment of skin physiology, is moving rapidly from a descriptive approach to a deeper understanding of biophysical and biochemical processes. This second edition of the popular text Bioengineering of the Skin: Water and Stratum Corneum reflects the progress in the field, focusing on t

Water and the Stratum Corneum, 2nd Edition

Marie Loden

Dry Skin and Moisturizers: Chemistry and Function presents new information relating to skin biochemistry and pathological changes seen in various dry skin disorders. The book examines the pharmacology of ingredients in moisturizing preparations, providing a broad overview of formulations as well as detailed information on ingredients. Featuring contributions from leading researchers from around the world, the book also outlines general principles for testing and evaluation of effects on the skin, with particular emphasis on safety assessment. This comprehensive book is divided into five parts. Part I, Dry Skin and Moisturizers, offers an introduction to this fascinating topic, while Part II, Biochemistry and Function of the Skin, explores everything from particle probes and skin physiology to the distribution and function of physiological elements in skin. Part III focuses on dry skin and hyperkeratotic conditions. Physico-chemical considerations, emulsifiers, hydrophilic pastes, lanolins, and other topics are addressed in Part IV, Formulations and Interactions with the Skin; while safety assessments, human in vivo skin irritancy testing, sensitive skin, and more are examined in Part V, Evaluation and Safety.

Chemistry and Function

Dry Skin and Moisturizers

Jean-Marie Lachapelle

Ali Alikhan

Hand eczema is a major complaint worldwide and a frequent occupational disorder. This book provides a comprehensive and detailed overview of the classification, etiology, diagnosis, prevention, and therapy of hand eczema. It is innovative, up to date, and practical. The links with particular occupations are explained, the various diagnostic tests are presented, and the role of different topical and systemic treatments is clearly described. The authors are world leaders in the field. The "Textbook of Hand Eczema" reflects a new era in hand dermatitis and will be invaluable for all who deal with the condition in their clinical practice.

Textbook of Hand Eczema

This authoritative and well-researched Second Edition covers everything from classification and immunology of the basic mechanism of eczema reaction, to clinical types (particularly irritant, allergic, atopic, and hyperkeratotic hand eczema), epidemiology, occupational aspects, and treatment modalities. The new information information on risk factors and chapters on toxicological and clinical aspects.

Hand Eczema

John Berth-Jones

Eunice Tan

Eczema can affect patients of all ages and few people are not affected to some degree at some point in their lives. Swift and accurate diagnosis coupled with the appropriate treatment regime is essential to avoid undue distress and suffering. 'Fast Facts: Eczema and Contact Dermatitis' is a concise, structured guide to the etiology, diagnosis and treatment of the various forms of eczema and contact dermatitis. Directed to the primary care physician, specialist nurse and other healthcare professionals, this is a concise and practical text written by experts. Superb illustrations and informative tables support an evidence-based approach which can be applied immediately for the benefit of patients in the clinical setting. • Succinctly and clearly summarises the clinical manifestations of eczema and contact dermatitis and the various treatment options • Clearly and concisely presented information supported by excellent illustrations • Contains all core information required by the primary healthcare team • Ideal text for medical students and trainee dermatologists Contents: • Allergic contact dermatitis • Irritant contact dermatitis • Atopic eczema • Photosensitive eczema • Seborrheic eczema • Hand and foot eczema • Other forms of eczema • Future trends • Useful resources

Fast Facts: Eczema and Contact Dermatitis

Evidence-based thinking in clinical medicine has impacted greatly on the physician's approach to clinical care. Evidence-Based Dermatology introduces and encourages the concept of evidence-based patient care in dermatology. Incorporating a text that is much more than merely the summary of trial data, the authors worked to explore disease mechanisms and treatments in greater depth and detail in order to provide more insight for the reader. In addition to promoting the understanding of the evidence-based philosophy, the authors have focused on some of the fundamentals in dermatology that need to be approached differently. Issues such as the interpretation of clinical research, disease-oriented evidence versus patient-care evidence, and the use of placebo are examined.

Evidence Based Dermatology

Aileen M. Feschuk

Rebecca M. Law

This book is a comprehensive volume dedicated to dermal absorption and decontamination. Given risks including chemical warfare and accidents with toxic industrial chemicals, studies involving dermal absorption and decontamination are of the utmost importance. Each chapter consists of a systematic review on an important dermal absorption and/or decontamination topic. Chapters address key issues such as the general acceptance of water/ soap and water as the gold standard of dermal decontamination despite the fact that it commonly provides incomplete decontamination and may even result in a "wash-in effect" an increased penetration of contaminant). Decontamination with other substances (e.g. RSDL) is explored, and factors that affect dermal penetration (e.g. anatomical variation) are summarized. All systematic reviews are comprehensive and up-to-date. Dermal Absorption and Decontamination will be useful for many fields and disciplines. Firstly, information on dermal decontamination may be used by governments for military and national defense purposes in the event of chemical warfare. Additionally, this information would be of use to many production companies, whose employees are at risk of an accident with toxic industrial chemicals. Topics covered in the book will also be of use to pharmaceutical companies, especially those exploring transdermal delivery of drugs and is of great relevance to those in the medical field, particularly dermatologists.

A Comprehensive Guide

Dermal Absorption and Decontamination

John Jenner

Vinod P. Shah

This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.

Howard I. Maibach

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