Angelo P. Giardino

Jordan S. Orange

Mark W. Kline

Mahesh M. Rathore

Z Leah Harris

Antonio Cabrera

The landmark pediatrics reference—updated with timely new content and more clinically relevant than ever Rudolph's Pediatrics has virtually defined the pediatric field for over a century, becoming one of the most important and well-respected pediatrics texts ever published. Renowned for its balance of clinical features and treatment of disease with underlying biological principles, this classic sourcebook has helped generations of pediatricians optimize their care of infants, children, and adolescents. This twenty-fourth edition of Rudolph's Pediatrics continues a long tradition of adapting its content to changes in our understanding of children's health and disease, providing an up-to-date, in-depth survey of pediatric medicine unmatched by any other text. With its algorithmic approach to pediatric systems, the book facilitates the diagnosis and treatment of both common and uncommon pediatric illnesses, and it reflects new technologies and advances in molecular medicine that continue to evolve with current thinking about normal childhood development and pediatric disease processes. Rudolph's Pediatrics, 24th Edition features: • New chapters on telemedicine and pandemics, and expanded section on behavioral health. • The most cohesive and consistent approach to clinical management of diseases and disorders of infants, children, and adolescents • Unmatched coverage of signs and symptoms • Expanded treatment algorithms • Expert coverage of general pediatrics and all the pediatric sub-specialties • Streamlined and consistent format for most chapters outlining Pathogenesis and Epidemiology, Clinical Manifestations, Diagnosis, Treatment, and Prevention • Hundreds of full-color illustrations and tables

Rudolph's Pediatrics, 24th Edition

Luigi D. Notarangelo

Eric Vivier

Emanuela Marcenaro

Natural Killer (NK) cells were discovered ca 1975, as the first group of lymphoid cells that were neither T cells nor B cells. Since then, the dissection of the biology of NK cells has been growing exponentially with many seminal discoveries from the identification of MHC class I-specific inhibitory receptors to the discovery of receptor-ligand pairs involved in NK cell activation and to the manipulation of NK cells in cancer. In this research topic, we asked a group of thought leaders in NK cell biology to review recent advances in their origins and biology, and their roles in cancer, infection and inflammation. Together, these 25 articles provide a timely survey of NK cells as critical immunologic components of health and disease. They will hopefully prompt further dialogue and developments in basic and translational immunology.

NK Cell Subsets in Health and Disease: New Developments

Jordan S. Orange

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