Savio L-Y. Woo

Joseph A. Buckwalter

Victor M. Goldberg

This work on the changes that occur with the ageing of soft tissue contains the results of experimental work that holds the promise of producing better musculoskeletal function in older people. It also includes clinically relevant information on improving strength and mobility.

Impact on Mobility

Musculoskeletal Soft-tissue Aging

This important book enables physicians to take full advantage of recent scientific progress to develop new, more effective treatment options. Orthopaedic surgeons, cell and molecular biologists, and bioengineers define current clinical issues and knowledge.

Clinical Issues and Basic Science Advances

Skeletal Growth and Development

J. F. Stoltz

Martin K. Lotz

"Osteoarthritis is a major public health issue due to its impact in term of handicap. Moreover, Ageing of the world population and outbreak of obesity in industrialized and non-industrialized countries will dramatically increase its incidence in the next years. Regarded as a multi-factorial disease, today mechanistic and inflammatory theories are no more opposed but, on the contrary, are framed within the same continuum: osteoarthritis, inflammation and degeneration. In order to collect major information in a benchmark book on the fundamental aspects of this disease, internationally well-known authors, from multiple specialties, gathered to analyse, dissect and finally try to understand the secrets of a disease which should no more be regarded as the common and relentless result of ageing or of passive wear but much more as an active disease able to benefit from the best targeted pharmacological (anti-cytokines, inhibitors of signalling pathways, inhibitors of proteases, etc.) and non-pharmacological (cellular therapy, gene therapy, cartilage engineering etc.) therapies, current and future."

A Continuum

Osteoarthritis, Inflammation and Degradation

Thomas A. Einhorn

Regis J. O'Keefe

A primer on the basic and molecualr science of orthopedics, authored by leading experts and teachers in the field.

Joseph A. Buckwalter

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