Kjell Fuxe

Jan-Åke Gustafsson

Lennart Wetterberg

Steroid Hormone Regulation of the Brain focuses on the advancement of knowledge of the properties of brain steroid receptors and steroid target nerve cells, including the actions of gonadal steroids, adrenocortical steroids, and androgenic steroids on the brain. The selection features the work of authors who have inspiringly conducted extensive studies on the action of steroid hormones. The book starts with discussions that point out that steroid hormones not only function through intracellular steroid receptors, but possibly through steroid membrane actions as well. Studies to support this claim are presented. As to the action of steroid hormones on presynaptic transmitter mechanisms, the book suggests that adrenocortical and gonadal steroids can create alterations in noradrenaline, adrenaline, and dopamine levels and turnover within the hypothalamus and preoptic area. The effects of catecholestrogens on the brain are also elaborated. A contribution to this paper stresses that estrogens have antidopaminergic action in the extrapyramidal system. This idea is identified through a series of behavioral experiments and measurements of the levels of striatal acetylcholine. This selection is recommended to scientists interested in studying the effect of hormones on the brain.

Proceedings of an International Symposium Held at the Wenner-Gren Center, Stockholm, 27-28 October 1980

Steroid Hormone Regulation of the Brain

Luigi F. Agnati

A New Intramembrane Integrative Mechanism

Receptor-Receptor Interactions

M. J. Goldstein

Irving Tabachnick

The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor isa molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral fuctions which might be altered in pathological states. A number of papers have recognized the interdependence of the regulatory functions of the D1 DA receptors with D2 and other receptor proteins, and vice versa. The biochemical, pharmacological and morphological characterization of the D1 and D2 DA receptor binding proteins, as well as of DARPP-32, illustrates the complex interactions between various macromolecules. Procedures described for the purification of the D1 and D2 DA receptor subtypes are fundamental for future studies on the mechanisms involved in the coupling of the receptor proteins with signal transducing systems. Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2 DA receptors, but in some instances reflect divergent neuronal activity of both systems. The knowledge of the physiology and biochemistry of the central DA receptor subtypes could lead to the development of a new generation of drugs which ameliorate some mental and neurological dysfunctions without producing severe undesirable side effects.

Central D1 Dopamine Receptors

Francisco Ciruela

Francesco Caciagli

Peter Illes

Henning Ulrich

Purinergic Signaling 2020: the State-of-The-Art Commented by the Members of the Italian Purine Club

Luigi Agnati

Receptor-Receptor Interactions: A New Intramembrane Integrative Mechanism

Detlev Ganten

Donald Pfaff

Neuroendocrinology of Mood

Computer Assisted Morphometry and Microdensitometry of Transmitter Identified Neurons with Special Reference to the Mesostriatal Dopamine Pathway

Proceedings of an International Symposium held at The Wenner-Gren Center, Stockholm,May 3–4, 1984

Quantitative Neuroanatomy in Transmitter Research

Peter J. Roberts

Robert Schwarcz

Proceedings of an International Symposium Held at The Wenner-Gren Center, Stockholm, August 26–27, 1982

Excitotoxins

Kjell Fuxe

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