Mustafa al'Absi

Magne Arve Flaten

Neuroscience of Pain, Stress, and Emotion: Psychological and Clinical Implications presents updated research on stress, pain, and emotion, all key research areas within both basic and clinical neuroscience. Improved research understanding of their interaction is ultimately necessary if clinicians and those working in the field of psychosomatic medicine are to alleviate patient suffering. This volume offers broad coverage of that interaction, with chapters written by major researchers in the field. After reviewing the neuroscience of pain and stress, the contents go on to address the interaction between stress and chronic/acute pain, the role of different emotions in pain, neurobiological mechanisms mediating these various interactions, individual differences in both stress and pain, the role of patient expectations during treatment (placebo and nocebo responses), and how those relate to stress modulation. While there are books on the market which discuss pain, stress, and emotion separately, this volume is the first to tackle their nexus, thus appealing to both researchers and clinicians. Represents the only comprehensive reference detailing the link between pain, stress and emotion, covering the neuroscientific underpinnings, related psychological processes, and clinical implications Compiles, in one place, research which promises to improve the methodology of clinical trials and the use of knowledge of pain-stress-emotion effects in order to reduce patients’ suffering Provides comprehensive chapters authored by global leaders in the field, the broadest, most expert coverage available

Psychological and Clinical Implications

Neuroscience of Pain, Stress, and Emotion

Per M. Aslaksen

Peter S. Lyby

Pain may be modulated by positive and negative emotions, and this is the basic element in the hypothesis that placebo effects are due to a reduction in negative emotions. Individual differences are discussed, especially as they relate to negative emotions. There is evidence that the placebo effect is partly due to a reduction in negative emotions. The role of positive emotions in placebo analgesia is less studied, and the data are mixed. The nocebo effect, the opposite of the placebo effect, can be explained by increased negative emotions. Taken together, the placebo and nocebo effects may be seen as different consequences of changes in emotional processes.

Chapter 8. Positive and Negative Emotions and Placebo Analgesia

Placebo and Pain

Luana Colloca

Karin Meissner

The placebo effect continues to fascinate scientists, scholars, and clinicians, resulting in an impressive amount of research, mainly in the field of pain. While recent experimental and clinical studies have unraveled salient aspects of the neurobiological substrates and clinical relevance of pain and placebo analgesia, an authoritative source remained lacking until now. By presenting and integrating a broad range of research, Placebo and Pain enhances readers’ knowledge about placebo and nocebo effects, reexamines the methodology of clinical trials, and improves the therapeutic approaches for patients suffering from pain. Review for Placebo and Pain: “This ambitious book is the first comprehensive and unified presentation of the placebo and nocebo phenomena in the area of pain. Written by the international leading experts in the field, the book provides an accurate up-to-date [work] on placebo and pain dealing with current perspectives and future challenging issues. --Ted Kaptchuk, Associate Professor of Medicine, Harvard Medical School Contains historical aspects of the placebo effect Discusses biological and psychological mechanisms of placebo analgesic responses Reviews implications of the placebo effect for clinical research and pain management Includes methodological and ethical aspects of the placebo effect

Magne Arve Flaten

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