Marianne J. Legato

لماذا لا يتذكر الرجال ويستحيل أن تنسى النساء

The announcement that we had decoded the human genome in 2000 ushered in a new and unique era in biomedical research and clinical medicine. This Third Edition of Principles of Gender-Specific Medicine focuses, as in the past two editions, on the essentials of sexual dimorphism in human physiology and pathophysiology, but emphasizes the latest information about molecular biology and genomic science in a variety of disciplines. Thus, this edition is a departure from the previous two; the editor solicited individual manuscripts from innovative scientists in a variety of fields rather than the traditional arrangement of sections devoted to the various subspecialties of medicine edited by section chiefs. Wherever it was available, these authors incorporated the latest information about the impact of the genome and the elements that modify its expression on human physiology and illness. All chapters progress translationally from basic science to the clinical applications of gender-specific therapy and suggest the most important topics for future investigation. This book is essential reading for all biomedical investigators and medical educators involved in gender-specific medicine. It will also be useful for primary care practitioners who need information about the importance of sex and gender in the prevention, diagnosis and treatment of illness. Outlines sex-specific differences in normal human function and explains the impact of age, hormones, and environment on the incidence and outcome of illness Reflects the latest information about the molecular basis of the sexual dimorphism in human physiology and the experience of disease Reviews the implications of our ever-improving ability to describe the genetic basis of vulnerability to disease and our capacity to alter the genome itself Illustrates the importance of new NIH guidelines that urge the inclusion of sex as a variable in research protocols

Gender in the Genomic Era

Principles of Gender-Specific Medicine

In "Eve's Rib, " medical pioneer Dr. Legato presents a revolutionary new understanding of the differences between the sexes. Individual chapters focus on the latest findings about organs and body systems, diseases, and treatments.

The Groundbreaking Guide to Women's Health

Eve's Rib

For decades, medicine saw men and women as essentially the same physically except in the area of reproduction. However, a new and groundbreaking science of gender-specific medicine has discovered astonishing distinctions between male and female bodies. From the thickness of our skin to the signs of a heart attack to ways we metabolize drugs, the sexes have significant physiological differences. But, what do these differences mean to you and your doctor? In this groundbreaking book, internationally respected academic physician and lecturer, Dr. Marianne Legato pulls together more than a decade of research into sex-specific health. The result is a powerful tool for anyone interested in the critical nuances in the ways men and women might present symptoms or be treated for disease. It’s a book that will not only change the way you think about women’s health, it just might save your life.

Awarded with the 2018 Prose Award in Clinical Medicine, the third edition of Principles of Gender-Specific Medicine explored and described exciting new areas in biomedicine that integrated technology into the treatment of disease and the augmentation of human function. Novel topics such as the sex-specific aspects of space medicine, the development and the use of genderized robots and a discussion of cyborgs were included in the third edition, providing a preview of the expanding world of sex-specific physiology and therapeutics. This Fourth Edition is a continuation of the mission to trace the relevance of biological sex to normal function and to the experience of disease in humans. We are now twenty years into the postgenomic era. The investigation of how the genome produces the phenome has led to fascinating insights as well as yet unanswered questions. Principles of Gender-Specific Medicine, Fourth Edition, has a central theme: discuss advances in understanding the role of epigenetics in regulating gene expression in a dynamic, sex-specific way during human life. It explores the protean role of epigenetics in human physiology, the relevance of environmental experience to human function, the therapeutic promise of cutting-edge methodologies like gene manipulation, the preparation of humans for space travel, the use of artificial intelligence in detection and therapeutic decisions concerning disease states, the possibilities for technological support of not only compromised individuals but of the augmentation of human function, and an analysis of the benefits, limitations and issues that surround our current expectations of personalized medicine. Covers the most important developments in biomedical research in the past decade, with a thoughtful analysis of how they impact patient care Discusses the feasibility and usefulness of personalized medicine, the limits and promise of genetic editing, the basis for variation in sexual identity and how artificial intelligence and technology will affect basic human function as well as correcting disability Promotes and facilitates discussions about the ethics and governance issues that surround much of what science is now able to do at the most basic levels of human’s physiology

Sex and Gender-Specific Biology in the Postgenomic Era

Laura Tucker

Existen diferencias biol&ógicas entre hombres y mujeres que determinan que los sexos aborden los problemas y las experiencias del mundo de modo muy distinto. La doctora Marianne J. Legato, creadora del concepto medicina espec&ífica de g&énero, propone c&ómo solucionar esta brecha. &¿Por qu&é los hombres no se comprometen? &¿Por qu&é las mujeres siempre quieren hablar de la relaci&ón? &¿Por qu&é &él es incapaz de ver que algo la est&á molestando? Pero quiz&á la pregunta m&ás importante que resuelve este libro es &¿por qu&é es tan dif&ícil que hombres y mujeres se entiendan entre s&í... y qu&é podemos hacer al respecto? Seg&ún la doctora Legato, los cerebros de hombres y mujeres son qu&ímica y estructuralmente diferentes. Los neurocient&íficos est&án descubriendo ahora c&ómo estas diferencias moldean la percepci&ón. &¿C&ómo cerramos esta brecha? La doctora Legato pone a nuestro alcance estrategias y consejos para aprender a "pensar" como el sexo opuesto y as&í superar nuestras diferencias. Este innovador libro fomentar&á el entendimiento entre los sexos en todos los niveles, tanto en las relaciones personales como en las profesionales.

Por qué los hombres nunca recuerdan y las mujeres nunca olvidan

The Plasticity of Sex: The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior provides a comprehensive view on the development of human sexuality. As there has been a crescendo of interest over the past several decades about the nature and diversity of human sexuality, this reference brings the evidence-based research into one place. The emergence of issues surrounding gender identity, genital ambivalence and the transition from one sex to another is striking, with the public and treating physicians alike clamoring for an evidence-based, comprehensive treatment of human sexuality and all its variations. This is a must-have reference for biomedical researchers in endocrinology, neuroscience, development biology, medical students, residents, and practicing physicians from all medical areas. Discusses the role of biology in gender identity from research in genetics, endocrinology and neuroscience Addresses important health disparities and how to address them when treating the transgender patient Reviews evidence-based information on the biological basis and impact of environmental and hormonal factors at different life stages Outlines schema for treating variations in the sexuality and sexual function of the individual patient

The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior

The Plasticity of Sex

John P. Bilezikian

Principles of Gender-Specific Medicine examines how normal human biology differs between men and women and how the diagnosis and treatment of disease differs as a function of gender. This revealing research covers various conditions that predominantly occur in men, and as well conditions that predominantly occur in women. Among the subjects covered are cardiovascular disease, mood disorders, the immune system, lung cancer as a consequence of smoking, osteoporosis, diabetes, obesity, and infectious diseases. * Gathers important information in the field of gender-based biology and clinical medicine, proving that a patient's sex is increasingly important in preventing illness, making an accurate diagnosis, and choosing safe and effective treatment of disease * Addresses gender-specific areas ranging from organ transplantation, gall bladder and biliary diseases, to the epidemiology of osteoporosis and fractures in men and women * Many chapters present questions about future directions of investigations

Principles of Gender-specific Medicine

Why won't he ask for directions? Why does she always want to talk about the relationship? Why is it so hard for men and women to understand each other . . . and what can we do about it? These are the kinds of questions that are resolved at last in this fascinating book from the founder of gender medicine. Dr. Marianne Legato not only confirms that men and women are different, but she uncovers the neuroscientific reasons behind the age-old disputes between the sexes, while providing a groundbreaking, authoritative, and reader-friendly guide to resolving them.

Why Men Never Remember and Women Never Forget

 Laura Tucker

Bărbaţii şi femeile gândesc diferit, percep în mod diferit importanţa lucrurilor şi privesc lumea în care trăiesc prin filtre absolut diferite. Acest adevăr nu este nicăieri mai pregnant decât la nivelul creierului, organul care găzduieşte tot ceea ce ne face umani: pasiunile, intuiţia, concepţia asupra lumii înconjurătoare, întreaga noastră viaţă intelectuală şi afectivă. Creierul masculin şi creierul feminin sunt extrem de diferite atât din punct de vedere chimic, cât şi structural, ceea ce explică de ce bărbaţii şi femeile abordează lumea în moduri atât de puţin asemănătoare. Cum putem depăşi această distanţă fiziologică? Dr. Marianne Legato prezintă în cartea de faţă strategii şi trucuri pentru a învăţa să gândim ca celălalt sex şi pentru a înlesni o comunicare de multe ori aflată în impas. O bună înţelegere a celui de lângă noi este primul pas către relaţii de cuplu mai sănătoase şi o viaţă sentimentală împlinită. Pentru toţi cei care au simţit vreodată perplexitate, furie, confuzie sau frustrare în relaţiile cu celălalt sex, această carte reprezintă un material informativ indispensabil, cu ajutorul căruia pot ,,sparge codul” şi se pot descifra unii pe alţii. Pentru că toţi ne naştem, creştem, ne îndrăgostim, ne căsătorim, iubim, înşelăm, procreăm, divorţăm, plângem, uităm şi iertăm. Pentru că suntem singuri sau împreună, pentru că suntem părinţi sau copii, pentru că ne pasă de cine suntem, de cei din jur, şi mai ales pentru că fiecare dintre noi are o familie pe care o iubeşte şi vrea să o protejeze. O colecţie intimă de sfaturi, probleme şi soluţii pentru fiecare membru al familiei; o familie cu adevărat fericită.

De ce femeile uită greu și bărbații repede

The Stressed Heart is truly unique in concept and will provide an eXCItmg adventure to the reader no matter what his or her field of expertise and interest. The title, although quite appropriate, does not adequately indicate the range of topics considered or the rational interrelationships among them. Indeed, perhaps the most important point to be learned from the book is that a serious consideration of the response of the heart to mechanical overload, ischemia, or excessive humoral stimuli must include evaluation of each of the topics in the table of contents. The heart responds to stress through alterations in both structure and function. How these changes are brought about is the subject of the initial chapters. These consider first the normal regulation of gene expression in the heart, the rapid response to mechanical overload that leads to both quantitative and qualitative changes in the contractile proteins, and our current understand ing of the signals that might be elicited by stress and alter gene expression. One chapter emphasizes the fact that, regardless of the nature of the stress, the common denominator is a discrepancy between energy requirements and expenditure. The central role of cellular acidosis in initiating the sequence of responses to stress and the possible roles of peptide regulators of transcription and protein regulators of translation are considered in detail.

The Stressed Heart

The field of gender-specific medicine examines how normal human biology and physiology differ between men and women and how the diagnosis and treatment of disease differs as a function of gender. This revealing research covers various conditions that predominantly occur in men as well conditions that predominantly occur in women. Among the areas of greatest difference are cardiovascular disease, mood disorders, the immune system, lung cancer as a consequence of smoking, osteoporosis, diabetes, obesity, and infectious diseases. The Second Edition of Principles of Gender-Specific Medicine focuses on the essentials of gender-specific medicine and the current study of sex and gender differences in human physiology and pathophysiology. New section editors, new chapter authors, and new chapters have been added to reflect the most up-to-date clinical research and practice. Offers insight into how the gender-specific risks of one organ system’s disease affects the health of other organ systems Outlines the sex-specific differences of normal anatomy and physiology Illustrates the gender-specific features and quantifies "gender" and "sex" as risk factors across all major diseases Qualifies and analyzes the results of new drug therapies designed with gender-specific differences in mind: ex, hormone therapy in men and women for the prevention and treatment of cardiovascular disease All chapters progress translationally from the basic science to the clinical applications of gender-specific therapies, drugs, or treatments Sections on drug metabolism, aging, and meta-analysis of data incorporated into all disease-specific chapters

Marianne J. Legato

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