David Raeburn

Mark A. Giembycz

Building on the existing titles in the "Airways Smooth Muscle" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo. The various animal models available for studying the bronchospasm and inflammation associated with human asthma are thoroughly reviewed by internationally recognised scientists. Specific chapters focus on the problems of administering drugs to animal airways, the mechanics of assessing lung function in the models, and describe in detail the species used, from rodents to primates. The use of genetically altered animals, an area of particular interest to molecular biologists, is also considered in depth. This up-to-date and extensively referenced work will prove invaluable to pharmacologists, physiologists and other biological scientists at all levels in academia and in the pharmaceutical industry.

Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo

Brian O'Connor

This book gives an up-to-date analysis of the epidemiology of asthma i n children and adults, the role of steroids in asthma management and n ew and novel asthma therapies. Specific chapters deal with the epidem iology of asthma mortality and of childhood asthma, others discuss the advantages and drawbacks of the use of b2-adenoreceptor agonists, cor ticosteroids, theophylline and new generation phosphodiesterase inhibi tors in the treatment of asthma. A new non-invasive method to assess a irway inflammation is also presented as well as steroid-sparing therap ies in asthma. The book addresses clinicians and basic scientists wit h an interest in asthma epidemiology, steroids and future therapies. I t is also of interest to clinical and no-clinical teachers in academic disciplines relating to respiratory disease.

Epidemiology, Anti-Inflammatory Therapy and Future Trends

Asthma

For researchers using animals to investigate human asthma, explains physiological and pharmacological process in the lung , and reviews the animal models available for studying the bronchospasm and inflammation associated with human asthma. Also discusses such methodological aspects as administering drugs to animal airways and the mechanics of assessing lung function. Also considers the use of genetically altered animals as research models. The sixth volume in the sub- series. Annotation c. by Book News, Inc., Portland, Or.

Mark A. Giembycz

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