Matthew M. Binns

Geoffrey L. Smith

Recombinant Poxviruses provides a comprehensive examination of poxviruses with an emphasis on the potential of these viruses as new vaccines. The book considers a wide range of issues involved in producing new genetically engineered live vaccines, such as efficacy, safety, stability, cost, host range, immune response, immunization route, use of multivalent vaccines, and need for revaccination. The opening chapter describes the origin of vaccinia virus, its use to eradicate smallpox, and the pathogenesis of poxvirus infections. Subsequent chapters examine the molecular biology of poxviruses, methods of constructing vaccinia virus recombinants, and applications; the use and immune responses induced by poxvirus recombinants as live vaccines; and the important issues of the safety and immunogenicity of vaccinia virus. The book's final two chapters report the progress that has been made developing avipoxviruses and parapoxviruses as candidate recombinant vaccines. Recombinant Poxviruses will be a welcome addition to the bookshelves of virologists, microbiologists, infectious disease specialists, and veterinarians.

Recombinant Poxviruses

Tony Morris

Matthew Binns

There are still many unknowns in the breeding of Thoroughbreds, but the international research coalition known as the Equine Genome Project is facilitating many new exciting discoveries. Dr Matthew Binns is a leader of the project, an enterprise set up to map the equine genome, and with racing historian and bloodstock authority Tony Morris has written this important book on the theory, practice, art and science of Thoroughbred breeding.This long-awaited book describes how man came to express pedigree and to develop theories about it, and how practical breeders behaved in the light of their understanding. It explains why many theories - including some still widely granted credibility today - are fallacious, examines the very real progress in knowledge since the principles of genetics were discovered, and focuses on the exciting developments of the last few years, when eminent geneticists have applied their expertise to the subject of the Thoroughbred.It has been the authors' endeavour to present that information in a form that may be readily understood by anyone who shares a love of the Thoroughbred and a fascination with what makes him what he is. Packed with absorbing history and cutting-edge science, this is a fascinating and illuminating book.

Matthew M. Binns

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