Carsten Nieder

Michael Molls

Peter Vaupel

Mitchell Steven Anscher

Te rapidly changing concepts in radiation oncology with the development of more precise - strumentation for delivery of radiation therapy and a greater emphasis on hypofractionation technologies require a very intimate knowledge of tumor biology and the infuence of various biologic factors on dose distribution within the tumor in terms of homogeneity as well as prev- tion of any late efects on normal tissue surrounding the tumor itself. Not only are these major factors in clinical practice but also the known factors of inhomogeneity of cancer cells, the impact of microenvironment in terms of radiation efect, and host factors make it mandatory to design therapeutic strategies to improve the outcome and to diminish any potential short-term or lo- term risks from the radiation therapy. Te authors have developed an outstanding text that deals with these strategies and how they would impact on established and emerging new technologies and treatment. Te context of the presentations within a multidisciplinary combined modality therapy program is incredibly - portant. In this volume, various topics are reviewed including tumor genesis, cell proliferation, - giogenesis, the physiologic characteristics of malignant tissues, invasion and adhesion, the route and role pursued in the development of metastasis, and the role of the human immune system in cancer prevention and development.

The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies

Klaus Mainzer

Ortwin Renn

Peter A. Wilderer

Martin Grambow

Here, expert authors delineate approaches that can support both decision makers as well as their concerned populations in overcoming unwarranted fears and in elaborating policies based on scientific evidence. Four exemplary focus areas were chosen for in-depth review, namely:- The scientific basis of risk management- Risk management in the area of environmental and ecological policy- Risk management in radiation medicine- Risk management in context with digitalization and roboticsGeneral as well as specific recommendations are summarized in a memorandum. Fundamental thoughts on the topic are presented in the introductory part of the book. The idea for and contents of the book were developed at a workshop on “Sustainable Risk Management: How to manage risks in a sensible and responsible manner?” held in Feldafing at Lake Starnberg (Germany) on April 14 to 16, 2016. The book offers important information and advice for scientists, entrepreneurs, administrators and politicians.

Sustainable Risk Management

J. Martin Brown

This book summarizes current knowledge on blood perfusion and the microenvironment of human tumors, enabling the reader to gain a deeper insight into the physiological components of malignant tumors. Among a range of topics, detailed consideration is given to circulatory parameters, including blood and nutrient supply, transvascular and interstitial transport, and oxygenation, as well as to bioenergetic status and the influence of pH on the responsiveness of malignant tumors to nonsurgical treatments such as radiotherapy and chemotherapy. For the clinician, it will be of special interest to read about the various invasive and noninvasive methods (including MR and PET) that allow the tumor physiology and microenvironment of an individual patient to be characterized.

Implications for Clinical Radiooncology

Blood Perfusion and Microenvironment of Human Tumors

Michael Molls

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