Nidhi Gupta

Computer Science Textbook with New Pedagogical Approaches KEY FEATURES ● National Education Policy 2020 ● Tech Funda: This section provides a practical information or tip to the students. ● Clickipedia: This section provides interesting computer facts. ● Lab Session: This is a lab activity to develop practical skills. (Subject Enrichment) ● Explore More: This section contains supplement topics for add-on knowledge. ● QR Code: Scan the QR Code given on the first page of each chapter to start chapter animation. ● Mind Boggler: This section has puzzle or fun based activity to help understand the concepts better. DESCRIPTION Computer technology has become essential and an integral part of life at work, in recreation, social networking and education too. With the constant development of new technology, it has become more significant in helping and preparing students for jobs. Computers have revolutionised the way education is imparted to children. Touchpad Plus Version 4.0 is a complete computer science curriculum solution for grades 1-8. It is based on Windows 10 and MS Office 2019, with new and future-ready content. Fun is the most important element of learning. Keeping in mind the concept of Joyful Learning, varied activities have been designed based on multiple intelligences and 21st century skills for holistic development. The books have a conversational style introduction of each chapter to make learning fun and engaging. The topics and their approaches are integrated in different themes as per ICT learning. Grade I and II books have four-line writing space to enhance writing skills in children. Each book is accompanied by digital learning resources that offer interesting animation and interactive tests for the student to supplement classroom learning with independent learning. The books are curated in a way that they make students and teachers equal partners in the learning process and take learning beyond classroom. We welcome and look forward to all meaningful and valuable suggestions for improving the book WHAT WILL YOU LEARN You will learn about: ● Digital World ● Cyber World ● Coding World ● Computational Thinking ● Artificial Intelligence WHO THIS BOOK IS FOR Grade 2

Windows 10 & MS Office 2019

Touchpad Plus Ver. 4.0 Class 2

Ramesh Chandra

Surendra Nimesh

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field

Nidhi Gupta

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