Agnes Bloch-Zupan

Pamela Den Besten

Stefan Habelitz

Catherine Chaussain

Michael Lansdell Paine

Elia Beniash

Rodrigo S. Lacruz

Wendy J. Shaw

Henry Margolis

Meerim K. Nurbaeva

The Research Topic will host an overview of the most recent knowledge on enamel issued from a group of international experts who gathered at the 10th International Symposium on Dental Enamel (Enamel X). The Topic will include manuscripts describing original data, short communication, and reviews. In addition, the Topic will host abstracts and panel discussions presented at the Enamel X meeting, to highlight changing paradigms, unsolved and challenging questions, as well as translational challenges. Bringing together physics, chemistry, biochemistry and development and differentiation, contributions to this Topic will focus on the unique architecture of enamel, from nano- to macro- scale, and the dynamic molecular interactions with lead to extracellular self-assembly and mineralization. This knowledge will open a window into innovative bioinspired treatment and materials for tissue repair and regeneration. Tissue-specific networks and pathways shared with a number of biological systems (clock genes, epithelial polarization/ion handling, cell niche dynamics, and cell signaling) will also be explored. This will give an overall picture of the multiple acellular, cellular and organismal (essentially transgenic mice) processes actively investigated in the enamel field. Similarly, lessons from isolated or syndromic, inherited and acquired enamel defects obtained using cutting edge cell and matrix-omics will establish the emerging genomic framework determining enamel quality. Tooth enamel defects reflect historical and present gene-environment interactions in the animal and human condition such as climate, nutrition, pollutants or fluoride exposures. This last fact is highly relevant in medicine and public health since poor tooth quality and mineral defects are one of the first human worldwide pathologies.

Tooth Enamel Research: Enamel 10 and beyond

Michel Goldberg

This book addresses the structural and biological properties of dental and peridental tissue structures and covers their mineralization process. The book contains a description of dentines, cementum, enamel and bone, including collagens, as well as non-collagenous proteins (SIBLINGs, SLRPs, GAGs, PGs, lipids, and MMPs). The mechanisms of mineralization are described in detail and the book is focused on matrix vesicles, collagen mineralization and the role of non-collagenous extracellular matrix components either as promoters or inhibitors of mineralization. In addition, the matrix components (non-collagenous) of enamel (amelogenin, ameloblastin, enamelin, MMP4, MMP20 and other proteases) are reviewed and their respective roles in dental tissues biomineralizations and tissue turnover are discussed. Additionally, environmental factors involved in enamel / dentin defects are adressed. With state-of-the-art contributions from experts in the respective domains, the book is a useful introduction to the field for junior scientists, interested in dental and peridental tissue biomineralization. It is also an interesting read for advanced scientists and clinicians working in dental research, giving them a broader view of the topic beyond their area of specialization. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.

Extracellular Matrix Biomineralization of Dental Tissue Structures

Pamela Den Besten

Books

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