Pavel Pevzner

Alexander Kulikov

Learning Algorithms Through Programming and Puzzle Solving is one of the first textbooks to emerge from the recent Massive Open Online Course (MOOC) revolution and a com- panion to the authors' online specialization on Coursera and MicroMasters Program on edX. The book introduces a programming-centric approach to learning algorithms and strikes a unique balance between algorithmic ideas, programming challenges, and puz- zle solving. Since the launch of this project on Coursera and edX, hundreds of thousands students tried to solve programming challenges and algorithmic puzzles covered in this book.The book is also a step towards developing an Intelligent Tutoring System for learning algo- rithms. In a classroom, once a student takes a wrong turn, there are limited opportunities to ask a question, resulting in a learning breakdown, or the inability to progress further without individual guidance. When a student suffers a learning breakdown, that student needs immediate help in order to proceed. Traditional textbooks do not provide such help, but the automated grading system described in this MOOC book does!The book is accompanied by additional educational materials that include the book website, video lectures, slides, FAQs, and other resources available at Coursera and EdX.

Learning Algorithms Through Programming and Puzzle Solving

Neil C. Jones

Pavel A. Pevzner

Algorithms and Complexity. Molecular Biology Primer. Exhaustive Search. Greedy Algorithms. Dynamic Programming Algorithms. Divide-and-Conquer Algorithms. Graph Algorithms. Combinatorial Pattern Matching. Clustering and Trees. Hidden Markov Models. Randomized Algorithms.

An Introduction to Bioinformatics Algorithms

Satoru Miyano

Michael Waterman

Jill Mesirov

Simon Kasif

Sorin Istrail

This volume contains the papers presented at the 9th Annual International Conference on Research in Computational Molecular Biology (RECOMB 2005), which was held in Cambridge, Massachusetts, on May 14–18, 2005. The RECOMB conference series was started in 1997 by Sorin Istrail, Pavel Pevzner and Michael Waterman. The list of previous meetings is shown below in the s- tion “Previous RECOMB Meetings. ” RECOMB 2005 was hosted by the Broad Institute of MIT and Harvard, and Boston University’s Center for Advanced - nomic Technology, and was excellently organized by the Organizing Committee Co-chairs Jill Mesirov and Simon Kasif. This year, 217 papers were submitted, of which the Program Committee - lected 39 for presentation at the meeting and inclusion in this proceedings. Each submission was refereed by at least three members of the Program Committee. After the completion of the referees’ reports, an extensive Web-based discussion took place for making decisions. From RECOMB 2005, the Steering Committee decided to publish the proceedings as a volume of Lecture Notes in Bioinf- matics (LNBI) for which the founders of RECOMB are also the editors. The prominent volume number LNBI 3500 was assigned to this proceedings. The RECOMB conference series is closely associated with the Journal of Compu- tional Biology which traditionally publishes special issues devoted to presenting full versions of selected conference papers. The RECOMB Program Committee consistedof42members,aslistedonaseparatepage. Iwouldliketothank the RECOMB 2005 Program Committee members for their dedication and hard work.

9th Annual International Conference, RECOMB 2005, Cambridge, MA, USA, May 14-18, 2005, Proceedings

Research in Computational Molecular Biology

Phillip Compeau

Bioinformatics Algorithms: an Active Learning Approach is one of the first textbooks to emerge from the recent Massive Online Open Course (MOOC) revolution. A light-hearted and analogy-filled companion to the authors' acclaimed online course (http://coursera.org/course/bioinformatics), this book presents students with a dynamic approach to learning bioinformatics. It strikes a unique balance between practical challenges in modern biology and fundamental algorithmic ideas, thus capturing the interest of students of biology and computer science students alike.Each chapter begins with a central biological question, such as "Are There Fragile Regions in the Human Genome?" or "Which DNA Patterns Play the Role of Molecular Clocks?" and then steadily develops the algorithmic sophistication required to answer this question. Hundreds of exercises are incorporated directly into the text as soon as they are needed; readers can test their knowledge through automated coding challenges on Rosalind (http://rosalind.info), an online platform for learning bioinformatics.The textbook website (http://bioinformaticsalgorithms.org) directs readers toward additional educational materials, including video lectures and PowerPoint slides.

An Active Learning Approach

Bioinformatics Algorithms

Pavel Pevzner

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