Riccardo Soffietti

Wolfgang Grisold

A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology. International list of contributors including the leading workers in the field. Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.

Neuro-oncology

Handbook of Clinical Neurology: Neuro-Oncology, Part I summarizes the present state of scientific and clinical knowledge in the field of neuro-oncology, including information related to diagnostic techniques such as imaging, along with immunology, molecular biology, and clinical aspects of tumors. Management and new therapeutic strategies for tumors, including gene therapy and molecularly targeted treatments, are also covered. Divided into eight sections encompassing 61 chapters, the book begins with an overview of the basic principles of tumors, including the epidemiology of primary central nervous system tumors, angiogenesis and invasion in cancer, the link between blood-brain barrier and brain edema, and the role of stem cells in gliomas. It proceeds with a discussion of diagnostic tools such as neuroimaging, the principles of tumor therapy such as radiotherapy and immunotherapy, and clinical trials in neuro-oncology. The reader is also introduced to specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. Furthermore, the book explains the neurological complications of systemic cancer and complications from treatments. This volume will appeal to clinicians and neuroscientists as well as researchers who want to gain a better understanding of the clinical features and management of the neurological manifestations of tumors. An invaluable resource that includes critical, in-depth insights into recent developments in neuro-oncology A fresh perspective on molecular biology, immunology, and other clinical aspects of tumors of the nervous system Extensive coverage of tumor management and new therapeutic strategies, including gene therapy and molecularly targeted treatments New tactics and therapies that will aid clinicians in their quest to provide optimal care for their neuro-oncological patients

Neuro-Oncology

Handbook of Clinical Neurology: Neuro-Oncology, Part II provides an overview of the most recent developments in the field of neuro-oncology, including new diagnostic imaging techniques, along with immunology, molecular biology, and clinical aspects of different types of tumors. It also considers management and new therapeutic strategies for tumors, such as gene therapy, radiation therapy, and molecularly targeted treatments. Divided into five sections encompassing 33 chapters, the book begins with a description of specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. It then discusses tumors at special sites, from brainstem tumors to peripheral nerve tumors, tumors of the meninges, and optic, hypothalamic, and thalamic tumors. It also explains the neurological complications of systemic cancer and the adverse effects of some treatments. Clinicians and neuroscientists, as well as researchers who read this book, will gain a better understanding of the clinical features and management of the neurological manifestations of tumors. Unique perspectives on advancements in the diagnosis and treatment of tumors of the nervous system An in-depth exploration of new strategies, including diagnostics, and gene and molecularly targeted therapies A state-of-the-art reference that summarizes the clinical features and management of the many neurological manifestations of tumors of the nervous system

Martin Klein

Michelangelo Bartolo

This book provides a comprehensive, practical, and timely guide to neurorehabilitation for patients affected by tumors of the central nervous system. These patients encounter various physical and psychosocial impairments, due to sensory-motor, psychological and cognitive limitations, as well as depression, anxiety and fatigue. These common tumor and treatment consequences reduce quality of life and produce long-term limitation in functioning and disability that may benefit from rehabilitative interventions. In the early stages of the disease, rehabilitation aims at restoring functioning after tumor treatment, while in the advanced stages, rehabilitation becomes an integral part of palliative care, which aims to increase patients’ independence, to prevent complications and to improve quality of life. Based on an interdisciplinary approach, the book is structured in two main parts. The first is devoted to the basics of cancer and to the main clinical features of the tumors of the nervous system, as well as to the essentials of therapeutic approaches. The second part is dedicated to rehabilitation issues, providing the tools for health personnel to take in charge persons affected by neuro-oncological disease. This unique volume is a valuable resource for all health professionals (physicians, psychologists, trainees nurses specialized in neuro-oncology, occupational therapists, physiotherapists, speech therapists) involved in the interdisciplinary management of individuals affected by tumors of the central nervous system.

Neurorehabilitation in Neuro-Oncology

Manmeet Ahluwalia

Philippe Metellus

This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.

Riccardo Soffietti

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