Shishir K. Maithel

Kenneth Cardona

The incidence of primary and metastatic liver tumors is rising and the therapeutic armamentarium for these tumors is expanding at a rapid pace. Surgery remains the primary treatment modality for these tumors. With improvements in our perioperative management and operative techniques a larger proportion of patients are able to undergo potentially curative liver surgery. In addition, indications and criteria for liver transplantation for both primary and metastatic liver tumors are constantly expanding. Unfortunately, many patients are not amendable to surgical resection or liver transplantation and therefore alternative liver-directed therapies are routinely being implemented as part of complex multidisciplinary treatment models. However, these models are continually evolving as these regional therapeutic options continue to expand. New embolization agents and techniques, as well as, improvements in radiation delivery, are all evolving in the background of improvement in systemic and targeted therapy options for these tumors. This book provides a comprehensive, state-of-the art review of the current state of liver-directed therapy for malignant liver tumors. The book will serve as a valuable resource for not only surgeons and clinicians but for researchers with an interest in malignant liver tumors. The book focuses on the therapeutic approach to primary and metastatic tumors providing an up-to-date review on surgical liver anatomy and new imaging techniques as well as patient selection and technical consideration for resection and transplantation. In addition, the book provides new insight into novel and evolving therapies in the areas of transarterial therapy such as: (i) bland embolization, (ii) chemoembolization, and (iii) radioembolization; as well as new radiation techniques including SBRT and proton therapy. Furthermore, the expanding role of hepatic artery infusion therapy in primary malignant tumors is highlighted. Finally, integration of all these regional therapy options with upcoming and evolving systemic and targeted therapy regimens are integrated and discussed. This book will serve as a very useful resource for clinicians and researchers managing and treating patients with these challenging malignancies. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information.

Treatment Strategy and Evolving Therapies

Primary and Metastatic Liver Tumors

Timothy M. Pawlik

Nipun B. Merchant

Advances in surgical technique and broadening indications for complex gastrointestinal procedures, surgical management of thoracic, hepato-pancreato-biliary, and colorectal diseases continues to evolve, but morbidity continues to be a persistent problem. This book provides a comprehensive, state-of-the art, definitive reference for the diagnosis and management of difficult-to-manage complications following advanced gastrointestinal surgery. All chapters are written by experts in their field and include the most up-to-date clinical information from national and world leaders in their respective discipline. The text provides a practical, clinically useful guide that reviews risk factors for these complications and offers key information on how to avoid potentially high morbidity events in the peri-operative period. It also discusses the management of these problems when they do occur. With its helpful guidelines and “tricks of the trade” to avoid potential complications, this book is essential to all medical professions treating such patients. Gastrointestinal Surgery: Management of Complex Perioperative Complications is of great value and utility for general surgeons, thoracic surgeons, upper gastrointestinal surgeons, colorectal surgeons, hepato-pancreato-biliary surgeons, surgical oncology fellows, thoracic surgery fellows and upper level residents in general surgery.

Shishir K. Maithel

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