Eric J. Nestler

Steven E. Hyman

Robert Malenka

* The most up-to-date and comprehensive coverage of the relationship of brain function and neuroactive chemicals * Authors are world-known leaders in the field * Molecular Neuropharmacology is the hot topic in medicine

A Foundation for Clinical Neuroscience

Molecular Basis of Neuropharmacology : A Foundation for Clinical Neuroscience

Karoly Nikolich

Experts from academia and industry discuss how to create a new, more effective translational neuroscience drawing on novel technology and recent discoveries. Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics, stem cell biology, and neuroscience emerged to offer new possibilities. In this volume, experts from both academia and industry discuss how novel technologies and reworked translation concepts can create a more effective translational neuroscience. The contributors consider such topics as using genomics and neuroscience for better diagnostics and biomarker identification; new approaches to disease based on stem cell technology and more careful use of animal models; and greater attention to human biology and what it will take to make new therapies available for clinical use. They conclude with a conceptual roadmap for an effective and credible translational neuroscience—one informed by a disease-focused knowledge base and clinical experience. Contributors Tobias M. Böckers, Thomas Bourgeron, Karl Broich, Nils Brose, Bruce N. Cuthbert, Ilka Diester, Gül Dölen, Guoping Feng, Richard Frackowiak, Raquel E. Gur, Stephan Heckers, Franz Hefti, David M. Holtzman, Steven E. Hyman, Nancy Ip, Cynthia Joyce, Tobias Kaiser, Edward H. Koo, Walter J. Koroshetz, Katja S. Kroker, Robert C. Malenka, Isabelle Mansuy, Eliezer, Masliah, Yuan Mei, Andreas Meyer-Lindenberg, Lennart Mucke, Pierluigi Nicotera, Karoly Nikolich, Michael J. Owen, Menelas N. Pangalos, Alvaro Pascual-Leone, Joel S. Perlmutter, Trevor W. Robbins, Lee L. Rubin, Akira Sawa, Mareike Schnaars, Bernd Sommer, Maria Grazia Spillantini, Laura Spinney, Matthew W. State, Marius Wernig

Toward New Therapies

Translational Neuroscience

First published in 2002. Routledge is an imprint of Taylor & Francis, an informa company.

The Science of Mental Health

Stress and the Brain

Robert C. Malenka

Market: Pharmacy and medical students; neuroscientists; neurologists; pharmacologists Updated edition has an attractive full-color design with more illustrations Includes numerous Fact Boxes to help reinforce learning

A Foundation for Clinical Neuroscience, Second Edition

Molecular Neuropharmacology

There has been a revolution in our understanding of mental illness and its effect on society. The science of mental illness has made enormous strides based on the just-completed "decade of the brain" and is poised to make quantum progress again based on the completion of the Human Genome Project. These and other developments are covered in this new multi-volume set, which brings together in one in-depth collection the most significant recent scholarship on mental and addictive disorders. The volumes are organized to provide cutting-edge views of the epidemiology, genetics, evolutionary perspectives, and brain and behavioral science of mental illness, as well as selected papers on treatment. The papers are selected from leading journals in the US and worldwide based on their significance and on the need to provide a balanced perspective. The collection offers a comprehensive and up-to-date overview, and includes introductions that make the technical aspects of the papers accessible.First Published in 2002. Routledge is an imprint of Taylor & Francis, an informa company.

Steven E. Hyman

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