Frederick R. Sidell

Timothy C. Marrs

Robert L. Maynard

This book is an accessible and authoritative guide to the practical medical management of victims of chemical warfare and offers an explanation of the underlying pharmacology and toxicology of the various agents. It discusses all major classical chemical warfare agents including nerve agents, vesicants, lung damaging agents, respiratory poisons, irritants and psychoactive agents covering the toxicology, pharmacology, human studies and treatment options for each class. Also features a section on field management of chemical agent exposure.

Toxicology and Treatment

Chemical Warfare Agents

Insects are more similar in structure and physiology to mammals than plants or fungi. Consequently, insecticides are often of greater toxicity to mammals than herbicides. This is particularly the case with neurotoxins. However, some insecticides are targeted at structures or hormonal systems specific to insects (insect growth regulators/chitin synthesis inhibitors) so are less harmful but can still be mildly haematotoxic. There are, therefore, issues specific to insecticides, which do not occur with other pesticides - hence the need for a book specifically on insecticide toxicology in mammals. The book starts with general issues relating to the mammalian toxicity of insecticides, including target/non-target specificity, nomenclature and metabolism of insecticides. It then goes on to discuss specific types of insecticides including: organochlorines; anticholinesterases; pyrethrum and synthetic pyrethroids; nicotine and the neonicotinoids; insect growth regulators/ecdysone agonists/chitin synthesis inhibitors; insecticides of natural origin; biological insecticides; and insecticides used in veterinary medicine.

Mammalian Toxicology of Insecticides

Bryan Ballantyne

Tore L. M. Syversen

General and Applied Toxicology

Tore Syversen

Encompassing 150 articles written by leading scientists in the field, the third edition of General and Applied Toxicology provides a comprehensive and in-depth review of the basic science of toxicology, its specializations, and the application of toxicological knowledge. This new edition reflects developments within the field that have taken place since the second edition was published in 1999. These include: New information developed in the areas of both the fundamental and applied aspects of toxicology Considerable increase in the development of fundamental information and its applications, refinement of technical methods, advances in mechanistic toxicology, and greater interest in areas of toxicology previously regarded as of limited scope Changing approaches to methodological, interpretative, regulatory, and ethical aspects of basic and applied toxicology General and Applied Toxicology, 3rd Edition is the first port of call for academic researchers, industrial researchers, regulatory professionals, and advanced students looking for timely and authoritative information in the field. Due to the increase in public and media interest in exposure to toxic substances, this provides an indispensable general reference source for general physicians, lawyers, law enforcement agencies, information resource facilities, and members of the general public. New online resource available now! In 2011, the content from the third edition of General and Applied Toxicology merged with the two-volume Handbook of Systems Toxicology. The result? General, Applied and Systems Toxicology - a new online resource combining traditional toxicology with the latest developments to present the ultimate reference in toxicology! For full details visit wileyonlinelibrary.com/ref/gast

Timothy C. Marrs

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