Toshikazu Yoshikawa

Free Radicals in Chemistry, Biology and Medicine

Lester Packer

Midori Hiramatsu

Antioxidant Food Supplements in Human Health discusses new discoveries in the areas of oxygen and nitric oxide metabolism and pathophysiology, redox regulation and cell signaling, and the identification of natural antioxidants and their mechanisms of action on free radicals and their role in health and disease. An essential resource for researchers, students, and professionals in food science and nutrition, gerontology, physiology, pharmacology, and related areas. Key Features * Health effects of antioxidant nutrients * Nutrients of vitamins C and E, selenium, alpha-lipoic acid, coenzyme Q10, carotenoids, and flavonoids * Natural source antioxidants, including pine bark, ginko biloba, wine, herbs,uyaku, and carica papaya

Antioxidant Food Supplements in Human Health

The Japanese Ministry of Health, Labor and Welfare, officially recognizing that various risk factors for disease are present in our environment, has proposed the concept of lifestyle-related diseases. These include those diseases that are tied to such lifestyle choices as excessive alcohol consumption, cigarette smoking, exposure to stress, and poor diet. Ongoing attention to this issue led to an International Symposium on Free Radicals and Health: Molecular Interventions and Protection of Lifestyle-Related Diseases bringing together the top experts in that area. With the belief that the recognition of the occurrence of risk factors and their identification are important to overcoming lifestyle-related diseases, three of those experts invited prominent participants at the symposium to contribute to a book. Molecular Interventions in Lifestyle-Related Diseases is the result of that effort. This book is divided into three main sections: Free Radicals, Lifestyle-Related Diseases, and Their Protection Free Radicals, Brain Diseases, and Their Protection Nutraceuticals, Functional Foods, Micronutrients, and Pharmacological Interventions When bad lifestyle choices cause oxidants and free radicals to have a negative influence on cell signaling and gene expression, lifestyle-related diseases are set into motion, which in turn lead to further oxidative stress. Molecular Interventions in Lifestyle-Related Diseases addresses the molecular basis of free radicals and lifestyle-related diseases and preventive/therapeutic approaches including the use of nutraceuticals, functional foods, and pharmacological interventions. Each section contains several chapters addressing critical molecular mechanisms, therapeutic interventions, and other issues of relevance to human health that will be of interest to students and researchers in the health professions including nutritional and environmental scientists, molecular and cell biologists and others in the biomedical community

Molecular Interventions in Lifestyle-Related Diseases

Satoshi Kokura

Takeo Ohnishi

This comprehensive work broadens readers' understanding of the rudimentary mechanism of the anti-cancer effect of hyperthermia. It also presents state-of-the-art clinical outcomes by hyperthermia treatment of cancer. In the past few decades, basic and clinical research have shown through in vitro experiments that hyperthermia inhibits epithelial-mesenchymal transition (EMT), resulting in the prevention of metastasis. It also has been learned that hyperthermia shows its superior benefit when applied in combination with radiation therapy, chemotherapy, or various immunotherapies as treatments of several types of carcinoma. The chapters here from expert contributors describe the details of their research for each type of cancer. This book provides not only an overview and the current status of hyperthermia but also its future perspectives. Therefore this volume will greatly benefit oncologists, radiologists and radiology technologists, and chemotherapists who are involved in immunotherapy for all kinds of cancer.

Hyperthermic Oncology from Bench to Bedside

Food factors are considered to be critical for human health promotion and play an important role in the prevention of life-style related diseases. One of the major challenges in this context is to determine the multiple factors associated with the causes of these diseases, as well as to develop a method of detecting changes in the initial stage and to establish a diagnostic approach that can be used in prevention studies of food factors.This publication features chapters on genomics, proteomics, bioavailability and safety, antioxidants, life-style related diseases and on chemoprevention and cancer. Basic scientists with a focus on food factors, clinicians planning a prospective preventive study of food factors in life-style-related diseases, as well as company researchers studying health promotional effects of food or food ingredients will find a wealth of information in this book.

Food Factors for Health Promotion

Kozi Asada

Reflecting upon the progress since the discovery of superoxide dismutase, these papers cover such topics as: reactive species of oxygen and its detection in vivo and in vitro; antioxidative enzymes and compounds; and the molecular mechanisms for adaption to oxidative stress.

Proceedings of the 6th International Conference on Superoxide and Superoxide Dismutase, Kyoto, Japan, October 11-15, 1993

Frontiers of Reactive Oxygen Species in Biology and Medicine

Shaw Watanabe

Hajime Ohigashi

Toshihiko Osawa

Junji Terao

Chemoprevention is currently regarded as one of the most promising avenues for the control of cancer, with human epidemiological and animal studies indicating that the risk of cancer may be modified by changes in diet. Over 100 papers are collected in this volume, the proceedings of the International Conference on Food Factors: Chemistry and Cancer Prevention, held in Hamamatsu, Japan, in December 1995. Special emphasis is placed on chemical, biological, and molecular properties of phytochemicals in teas, fruit, vegetables, herbs, and spices, and on their potential for cancer prevention. Also discussed are the cancer-preventive effects of vitamins, lipids, carotenoids, flavonoids, and other components of diet. The findings presented here will be invaluable to all who are interested in diet and cancer prevention, and especially to biochemists, pharmacologists, food scientists, and nutritionists.

Food Factors for Cancer Prevention

Yuji Naito

An overview on the role of various gaseous molecules in health and disease The substantial biological importance of gaseous mediators in various physiological-pathological conditions has been realized only recently, but to date, the detailed mechanisms involved remain elusive. The publication at hand contains 16 overviews written by a panel of experts who summarize the current knowledge and provide fundamental insights into the roles of gaseous molecules in signal transduction in biological systems. The first part provides a comprehensive overview on gaseous mediators in health and disease. In the second part, the medical application of various molecules such as nitric oxide, carbon monoxide, hydrogen sulfide, hydrogen, acetone and phytoncide are discussed. Furthermore, articles on skin gas biology and Carbon-13 (13C), especially clinical applications of 13C-labeled substrate are included. This book provides valuable information not only for basic researchers in physiology and biochemistry, but also for gastroenterologists and clinicians who wish to learn more about the role of gaseous mediators.

Gas Biology Research in Clinical Practice

Antioxidant Food Supplements in Human Health discusses new discoveries in the areas of oxygen and nitric oxide metabolism and pathophysiology, redox regulation and cell signaling, and the identification of natural antioxidants and their mechanisms of action on free radicals and their role in health and disease. An essential resource for researchers, students, and professionals in food science and nutrition, gerontology, physiology, pharmacology, and related areas. Health effects of antioxidant nutrients Nutrients of vitamins C and E, selenium, alpha-lipoic acid, coenzyme Q10, carotenoids, and flavonoids Natural source antioxidants, including pine bark, ginko biloba, wine, herbs,uyaku, and carica papaya

Makoto Suematsu

There is a growing body of experimental and clinical data to suggest that the organs of the digestive system may be subjected to considerable oxidative stress associated with acute and chronic inflammation. Although inflammation and ischemia play a key role in producing oxygen-derived free radicals in the digestive tract, the contribution of other factors, such as transition metal imbalances, lipid and glucose metabolic disturbance, and the interaction with gaseous molecules including nitric oxide and carbon monoxide, has also been suggested. Recent studies have demonstrated that several biomarkers indicating oxidative stress-mediated damage may help in monitoring the degree of disease and planning the design of new therapeutic strategies. In addition, recent advances in 'omics' research (genomics, proteomics, metabolomics, etc.) may bring a breakthrough in the field of gastroenterology and hepatology: Several molecular targets for oxidative stress have been presented by the 'omics'. This book includes up-to-date reviews on the relevant issues in free radical biology in a combination with expert basic research reviews and clinical aspects in gastroenterology and hepatology. Providing information about new molecular targets for the treatment or prevention of digestive diseases, this book should be read by clinical and basic researchers in gastroenterology and hepatology.

Toshikazu Yoshikawa

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