Ziv Shkedy

Ariel Alonso

Theophile Bigirumurame

Tomasz Burzykowski

Marc Buyse

Geert Molenberghs

Leacky Muchene

Nolen Joy Perualila

Wim Van der Elst

An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment’s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate endpoint that can be measured in a more convenient or cost-effective way. This book focuses on the use of surrogate endpoint evaluation methods in practice, using SAS and R.

Applied Surrogate Endpoint Evaluation Methods with SAS and R

Wim Van der Elst

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