Bo Yang

Yang Song

Yijie Zhou

A disease is defined as rare if the prevalence is fewer than 200,000 in the United States. It is estimated that there are more than 7,000 rare diseases, which collectively affect 30 million Americans or 10% of the US population. This diverse and complex disease area poses challenges for patients, caregivers, regulators, drug developers, and other stakeholders. This book is proposed to give an overview of the common issues facing rare disease drug developers, summarize challenges specific to clinical development in small populations, discuss drug development strategies in the evolving regulatory environment, explain generation and utilization of different data and evidence inside and beyond clinical trials, and use recent examples to demonstrate these challenges and the development strategies that respond to the challenges. Key Features: • Rare disease. • Drug development. • Innovative clinical trial design. • Regulatory approval. • Real-world evidence.

Drug Development for Rare Diseases

This book explores China's hukou system, by which individuals are registered in a specific geographic region, and the prospects for reform. The history of the hukou system and its instrumental role in Chinese urbanization and labor markets is explained, and readers get a sense of what issues are prioritized by Chinese policymakers as they contemplate reform or change to this system, from hukou-based labor market discrimination, inequality of opportunity, multi-dimensional poverty of rural migrants, the public health consequences of non-hukou migration, and old age insurance for migrants without hukous. The author concludes with a stirring and practical call for hukou reform, articulating a cost-benefit model and providing an array of policy suggestions. This book will interest scholars of Chinese society, demographics and future urbanization.

Facts, Impacts, and Reform Paths

A Deep Analysis of the Chinese Hukou System

This book proposes a genre-aware, semiotic-aware, critical framework that aims at analyzing digital literacies required and practiced by online journalists. It simultaneously encompasses dimensions of professional culture, professional practices, and abstraction of instantiated meaning making via multimodal semiotic resources.

A Genre-aware Approach to Online Journalism Education

Multimedia News Storytelling as Digital Literacies

Minrui Fei

Zhou Su

Chen Peng

Qinglong Han

This book constitutes the second part of the refereed proceedings of the International Conference on Life System Modeling and Simulation, LSMS 2014, and of the International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2014, held in Shanghai, China, in September 2014. The 159 revised full papers presented in the three volumes of CCIS 461-463 were carefully reviewed and selected from 572 submissions. The papers of this volume are organized in topical sections on advanced neural network theory and algorithms; advanced evolutionary computing theory and algorithms, such as particle swarm optimization, differential evolution, ant colonies, artificial life, artificial immune systems and genetic algorithm; fuzzy, neural, and fuzzy-neuro hybrids; intelligent modeling, monitoring, and control of complex nonlinear systems; intelligent modeling and simulation of climate change; communication and control for distributed networked systems.

International Conference on Life System Modeling and Simulation, LSMS 2014 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2014, Shanghai, China, September 2014, Proceedings, Part II

Yang Song

Books

Your next favorite book is out there