Yves Christen

Paolo Sassone-Corsi

Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.

A Time for Metabolism and Hormones

Antonio R. Damasio

Hanna Damasio

Neuroscience has paid only little attention to decision-making for many years. Although no field of science has cohered around this topic, a variety of researchers in different areas of neuroscience ranging from cellular physiology to neuropsychology and computational neuroscience have been engaged in working on this issue. Thus, the time seemed to be ripe to bring these researchers together and discuss the state of the art of the neurobiology of decision-making in a broad forum. This book is a collection of contributions presented at that forum in Paris in October 1994 organized by the Fondation IPSEN.

Neurobiology of Decision-making

Few people realize how much science can tell us about the differences between men and women. Yves Christen, provided the first comprehensive overview of research in this area when this classic book was first published in the1990s. He goes beyond simplistic biology is destiny arguments and constructs a convincing case for linking social and biological approaches in order to understand complex differences in behavior.Biologists agree that the sexes differ in brain and body structure. Christen links these differences in cerebral anatomy to differences in behavior and intellect. Taking his readers on a journey through psychology, endocrinology, demography, and many other fields, Christen shows that the biological and the social are not antagonistic. To the contrary, social factors tend to exaggerate the biological rather than neutralize it.This controversial work, Sex Differences, takes on traditional feminism for its refusal to confront the evidence on biologically determined sex differences. Christen argues for a feminism that sees traits common to women in a positive light, in the tradition of such early feminists as Clemence Royer and Margaret Sanger, as well as more contemporary feminist sociobiologists like Sarah Hrdy. We deny sex differences only at the price of scientific truth and our own self-respect.

Modern Biology and the Unisex Fallacy

Sex Differences

Paolo Sassone Corsi

Recent years have seen spectacular advances in the filed of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigentic regulation to brain functions has been accumulationg. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molcular mechanisms implicated in epigentic control and how these may operte in concert. It will be critical to unravel how specifity is achieved. The focus of this volume is on critical epigenetic regulation and chromatin remodeling events that occur in the nervous system and on the presumed mechanisms that operate within neurons to translate them into long-lasting neuronal responses.

Epigenetics, Brain and Behavior

Mathias Jucker

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer ́s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society. ​

Proteopathic Seeds and Neurodegenerative Diseases

J.-C. Carel

Paul A. Kelly

Growth is a complex process that is essential to life. Not only does size play an important role in the process of cellular proliferation, but body size is also a critical factor in determining which organisms live longer. Evolution has been characterised by a dramatic increase in an organism’s body size, which is not only limited to the size of the brain.

Deciphering Growth

Thomas Curran

Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes

Two Faces of Evil: Cancer and Neurodegeneration

Jonathan R Seckl

The authors address in particular the role of hormones and their links with other maternal environmental mediators in developmental programming. The crucial nature of the placenta as an interface and target between maternal and foetal environments is addressed. Emphasis is made on the emerging science of epigenetics as a potential explanation for how environmental events that occur during brief windows of development may exert effects that impact upon somatic cells through many rounds of mitosis for much of the life span of the subsequent organism.

Hormones, Intrauterine Health and Programming

Henry Kennedy

David C. Van Essen

This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.

Micro-, Meso- and Macro-Connectomics of the Brain

György Buzsáki

This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The individual chapters cover several fascinating facets of contemporary neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Each of these topics require appropriate levels of analyses with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks, supplemented by models and theories to explain how different levels of brain dynamics interact with each other and how the failure of such interactions results in neurologic and mental disease. While such complex questions cannot be answered exhaustively by a dozen or so chapters, this volume offers a nice synthesis of current thinking and work-in-progress on micro-, meso- and macro- dynamics of the brain.

Micro-, Meso- and Macro-Dynamics of the Brain

Donald W Pfaff

In theoretical terms, sex differences in brains and behaviors of laboratory animals offer the possibility of fascinating scientific studies on a range of molecular phenomena such as genomic imprinting, DNA methylation, chromatin protein modification, non-coding DNA, potentially resulting in important neuroanatomical and neurochemical sex differences in the brain. Such sex differences could arise consequent to exposures to testosterone early in development, or to other effects deriving from the Y chromosome. However, this general subject has been treated with much hyperbole. Historically, sex differences were assumed to be present where they did not really exist, e.g. with respect to mathematics, executive leadership, etc. etc. Under what circumstances do we really care about sex differences in brain and behavior? These circumstances concern human maladies whose diagnoses are much different between boys and girls, or between women and men. Prominent examples discussed in this volume include autism, attention deficit hyperactivity disorders and congenital adrenal hyperplasia. In fact, infant boys are more susceptible than infant girls to a variety of disorders that arise early in development. This volume then ends with a consideration of effects of estrogenic hormones on the injured brain, and their roles as protective agents.

Neuroendocrine Functions and their Pathologies

Multiple Origins of Sex Differences in Brain

Longtemps nous avons considéré les animaux comme ceux que la nature avait privés des qualités que nous, les humains, possédons : l'aptitude à raisonner, apprendre, communiquer, s'adapter, décoder, transmettre, enseigner, progresser... Les travaux scientifiques ont pulvérisé cette idée reçue, et depuis la dernière décennie, ils nous surprennent encore plus. Qui sont vraiment les animaux ? On les savait joueurs, blagueurs, rieurs, féroces parfois ; on les découvre tricheurs, menteurs, trompeurs, mais aussi aimants, mélancoliques ou encore émotifs, stratèges, sensibles aux intentions d'autrui, capables de respecter une morale ou d'élaborer une culture. La très grande ingéniosité des tests et l'extraordinaire diversité des observations scientifiques (éthologie, génétique, psychologie, zoologie, primatologie, neurosciences) nous révèlent les facettes de l'intelligence et de l'identité animales, et prouvent l'absurdité qu'il y a à réduire les compétences de la bête à la seule force de son instinct. Car en dépit des caractéristiques qui fondent l'homogénéité de son espèce, chaque animal est un individu à part entière, un être social unique, complexe, et par là même un sujet de droit. Des singes aux léopards, des éléphants aux antilopes, des baleines aux dauphins, l'auteur nous propose une approche de l'altérité qui apporte beaucoup au débat sur l'exploitation et la manipulation animales. Un plaidoyer fort documenté en faveur de la personne animale.

L'animal est-il une personne?

Stanislas Dehaene

Fifteen of the foremost scientists in this field presented testable theoretical models of consciousness and discussed how our understanding of the role that consciousness plays in our cognitive processes is being refined with some surprising results.

Characterizing Consciousness: From Cognition to the Clinic?

Jean Decety

Traditionally, neuroscience has considered the nervous system as an isolated entity and largely ignored influences of the social environments in which humans and many animal species live. However, there is mounting evidence that the social environment affects behavior across species, from microbes to humans. This volume brings together scholars who work with animal and human models of social behavior to discuss the challenges and opportunities in this interdisciplinary academic field.

Yves Christen

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