This Handbook assembles state-of-the-art insights into the co-evolutionary and precarious relations between science and public policy. Beyond this, it also offers a fresh outlook on emerging challenges for science (including technology and innovation) in changing societies, and related policy requirements, as well as the challenges for public policy in view of science-driven economic, societal, and cultural changes. In short, this book deals with science as a policy-triggered project as well as public policy as a science-driven venture.