This book constitutes the proceedings of the 16th International Symposium on Applied Reconfigurable Computing, ARC 2020, held in Toledo, Spain, in April 2020. The 18 full papers and 11 poster presentations presented in this volume were carefully reviewed and selected from 40 submissions. The papers are organized in the following topical sections: design methods & tools; design space exploration & estimation techniques; high-level synthesis; architectures; applications.