Thrombolytic therapy for stroke with the introduction of tissue plasminogen activator (t-PA) was a boon to stroke physicians, since it meant that morbidity and mortality could be reduced with the optimal use of t-PA. The editor and his well-respected contributors offer the reader their personal perspectives on the evidence-based use of various thrombolytic and anti-thrombotic agents that are available and that can provide successful outcomes. Thrombolytic and Antithrombotic Therapy for Stroke is updated and thoroughly referenced. Everyone working in the casualty/emergency room must read this clearly-written text.