When a monkey named Jojo found his "Mojo," it was bad news for the Powerpuff Girls! Blossom, Bubbles, and Buttercup have dedicated their lives to fighting crime and the forces of evil. Mojo Jojo has dedicated his life to crushing the Powerpuff Girls. But...oh, no! could it be that Mojo's major mistake is the reason Blossom, Bubbles, and Buttercup have superpowers in the first place?