Dr. Brown provides a timely upate on the clinical diagnosis and management of Hepatic Encephalopathy. His issue addresses current hot topics including Role of NH4 in Pathogenesis of Hepatic? Encephalopathy; How to diagnose and manage HE in fulminant hepatic failure;? New methods of Brain Imaging and testing (eg PET) and Hepatic Encephalopathy; Management New agents for HE (focus on NH4 lowering drugs used in UCD); Legal responsibility of MD when he diagnoses HE; Diets in Encephalopathy; and Neurological manifestations of HE.