When an Englishman receives an invitation from an American university, he embraces it as a jubilant new beginning. Instead, on arrival, he is stricken with a persistent inability to stand up or think straight. Diagnosed with ME disease—also called chronic fatigue syndrome—he moves restlessly across his newly adopted country, searching for a love and a life suited to his new condition. Love and Fatigue in America briskly compresses an illness, a nation, and an era in a masterly blend of literary forms.