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Our first Research Topic entitled “Current and Future Role of Artificial Intelligence in Cardiac Imaging” provided comprehensive reviews of the recent advances and potential impact of AI for a range of cardiac imaging applications and remains available as an e-book to download at no cost. Since this first set of publications, the field has moved at pace and it is timely to now invite further up-to-date and topical reviews but importantly original research articles via our Research Topic “Current and Future Role of Artificial Intelligence in Cardiac Imaging 2.0”.