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In this paper, the concept of generalized neutrosophic pre-closed sets and generalized neutrosophic pre-open sets are introduced. We also study relations and various properties between the other existing neutrosophic open and closed sets. In addition, we discuss some applications of generalized neutrosophic pre-closed sets, namely neutrosophic pT12 space and neutrosophic gpT12 space. The concepts of generalized neutrosophic connected spaces, generalized neutrosophic compact spaces and generalized neutrosophic extremally disconnected spaces are established. Some interesting properties are investigated in addition to giving some examples.