This book constitutes the proceedings of the International Conference on Brain Informatics and Health, BIH 2015, held in London, UK, in August/September 2015. The 42 full papers presented were carefully reviewed and selected from 82 submissions. Following the success of past conferences in this series, BIH 2015 has a strong emphasis on emerging trends of big data analysis and management technology for brain research, behavior learning, and real-world applications of brain science in human health and wellbeing.