Michael Simons

Gabor M Rubanyi

This volume addresses current emerging concepts in the field of angiogenesis, including important angiogenesis modifiers which are essential in combination with growth factors (VEGF and FGF) for the physiological process and also for therapeutic applications. It covers many of the lesser discussed areas including blood vessel growth guidance (interactions with CNS) as well as emerging practical applications of these concepts. The book comprises in-depth reviews by leading experts in several major areas: recent basic science discoveries about angiogenesis modifiers (semaphorins, ephrins and nitric oxide, for which the Nobel Prize was awarded); arterial guidance; clinical applications of new angiogenic factors (HGF, HIF and eNOS); and basic and clinical advancement of anti-angiogenic molecules for the treatment of cancer and macular degeneration (tyrosine kinase inhibitors and NO). These topics, especially their unique combination presented in this volume, are not found in any other current books on angiogenesis. This makes the book a must-read for readers both interested and actively involved in the most recent advances in basic principles and clinical applications of angiogenesis. Contents:Semaphorins, Plexins and Neuropilins and Their Role in Vasculogenesis and Angiogenesis (G Neufeld et al.)EPH Receptors and Ephrins (E B Pasquale)The FGF Family of Angiogenic Growth Factors (P Auguste & A Bikfalvi)Neuropeptide Y: Neurogenic Mediator of Angiogenesis and Arteriogenesis (J B Kitlinska & Z Zukowska)Modulation of Growth Factor Signaling by Heparan Sulfate Proteoglycans (N W Shworak)Directional Cues in Angiogenesis (A Horowitz)Regulation of Angiogenesis and Arteriogenesis by Hypoxia-Inducible Factor 1 (G L Semenza)Redox State and Regulation of Angiogenic Responses (M Ushio-Fukai & R W Alexander)Angiogenesis and Arteriogenesis in Cardiac Hypertrophy (R J Tomanek & E I Dedkov)Regulation of Coronary Vascular Tone and Microvascular Physiology (B Ramlawi et al.)Kinase Inhibitors: Cancer Drugs Derived from Mechanistic Considerations (K-H Thierauch & A Chlistalla)Therapeutic Angiogenesis — An Overview (M Murakami & M Simons)Hepatocyte Growth Factor (R Morishita & T Ogihara)Role of Nitric Oxide in Adult Angiogenesis: Therapeutic Potential of Endothelial Nitric Oxide Synthase Gene Transfer (G M Rubanyi) Readership: Vascular biologists; trainees in vascular biology, cardiology and cancer medicine; clinicians interested in basic science of angiogenesis; industrial scientists; biotechnology companies. Keywords:Arteriogenesis;Angiogenesis;Arterial Guidance;Clinical Trials;Endothelial Cells;Regulation of Signaling;Nitric Oxide;Periferal Vascular Disease;Myocardial Ischemia;Therapeutic Angiogenesis;RevascularizationKey Features:Contains a detailed discussion of arterial guidanceCovers angiogenesis modifiers not discussed in-depth in any other book (semaphorins and nitric oxide synthase)Includes the most recent clinical advances in therapeutic angiogenesis (HGF and HIF)Deals with basic and clinical aspects of anti-angiogenic therapy for cancerDiscusses translational applicationsWritten by leading experts on the most recent emerging topics

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