Nick P. Goplen

Shiki Takamura 

Chaofan Li

As we learn more about the intricacies of immune interactions, the goalposts of ideal vaccination strategies change. It has become apparent that for many pathogens, immunizations should seek to optimize lymphocyte-mediated protection at their portals of entry, which is not likely to be accomplished with current intramuscular jabs. However, there are increased reports suggesting resident memory CD4 and CD8 T cells may, or indeed do, cause pathologies in the lung, gut, skin, pancreas, CNS, and adipose tissue. This is following chronic infection, immunization, or sensitization and it is becoming clearer that protective immunity ought to be finely balanced with the pathogenic capacity of the resident cells providing the immunity. Alternatively, in instances like asthma or inflammatory bowel disease (IBD) where the bulk of resident CD4 or CD8T cells’ pathogenic capacity is not restrained, understanding the mechanisms of escape from immune regulation may be key. Thus we are interested in soliciting works that seek to provide a deeper mechanistic understanding of the balance of immunity and pathology that local resident memory T cells must successfully display in order to build upon the existing dogma regarding ideal vaccination strategies.

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